Kumar Ravinder
Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, Haryana, INDIA.
Chem Asian J. 2024 Jan 2;19(1):e202300705. doi: 10.1002/asia.202300705. Epub 2023 Dec 14.
1,2-Diamines are synthetically important motifs in organo-catalysis, natural products, and drug research. Continuous utilization of transition-metal based catalyst in direct 1,2-diamination of olefines, in contrast to metal-free transformations, with numerous impressive advances made in recent years (2015-2023). This review summarized contemporary research on the transition-metal catalyzed/mediated [e. g., Cu(II), Pd(II), Fe(II), Rh(III), Ir(III), and Co(II)] 1,2-diamination (asymmetric and non-asymmetric) especially emphasizing the recent synthetic methodologies and mechanistic understandings. Moreover, up-to-date discussion on (i) paramount role of oxidant and catalyst (ii) key achievements (iii) generality and uniqueness, (iv) synthetic limitations or future challenges, and (v) future opportunities are summarized related to this potential area.
1,2 - 二胺在有机催化、天然产物和药物研究中是具有重要合成意义的结构单元。与无金属转化相比，过渡金属基催化剂在烯烃的直接1,2 - 二胺化反应中持续得到应用，近年来（2015 - 2023年）取得了众多令人瞩目的进展。本综述总结了过渡金属催化/介导的[例如，Cu(II)、Pd(II)、Fe(II)、Rh(III)、Ir(III)和Co(II)] 1,2 - 二胺化反应（不对称和非不对称）的当代研究，特别强调了近期的合成方法和机理认识。此外，还总结了关于（i）氧化剂和催化剂的关键作用（ii）主要成就（iii）通用性和独特性，（iv）合成局限性或未来挑战，以及（v）与这一潜在领域相关的未来机遇的最新讨论。
