Loomba Rohit S, Villarreal Enrique G, Flores Saul, Farias Juan S, Constas Alex
Advocate Children's Hospital, Chicago, IL, USA.
Department of Pediatrics, Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo Leon, Mexico.
Pediatr Cardiol. 2025 Jan;46(1):39-45. doi: 10.1007/s00246-023-03302-x. Epub 2023 Sep 24.
Continuous monitoring software, T3, has an integrated index called the inadequate oxygen delivery index 50% (IDO2-50) which displays a probability that the mixed venous saturation is below a user-selected threshold of 30-50%. The primary aim of this study was to determine the correlation of the IDO2-50 with a measured venous saturation. The secondary aim of this study was to characterize the hemodynamic factors that contributed to the IDO2-50. This single-center, retrospective study aimed to characterize the correlation between IDO2-50 and inferior vena cava (IVC) saturation. A Bayesian Pearson correlation was conducted to assess the correlation between the collected variables of interest, with a particular interest in the correlation between the IDO2-50 and the IVC saturation. Receiver operator curve (ROC) analysis to assess the ability of the IDO2-50 to identify when the venous saturation was less than 50%. Bayesian linear regression was done with the IDO2-50 (dependent variable) and other independent variables. A total of 113 datasets were collected across 15 unique patients. IDO2-50 had moderate correlation with the IVC saturation (correlation coefficient - 0.569). The IDO2-50 had a weak but significant correlation with cerebral near-infrared spectroscopy (NIRS) values, a weak but significant correlation with heart rate, and a moderate and significant correlation with arterial saturation. ROC analysis demonstrated that the IDO2-50 had a good ability to identify a venous saturation below 50%, with an area under the curve of 0.797, cutoff point of 24.5 with a sensitivity of 81%, specificity of 66%, positive predictive value of 44%, and negative predictive value of 91%. Bayesian linear regression analysis yielded the following model: 237.82 + (1.18 × age in months) - (3.31 × arterial saturation) - (1.92 × cerebral NIRS) + (0.84 × heart rate). The IDO2 index has moderate correlation with IVC saturation. It has good sensitive and negative predictive value. Cerebral NIRS does appear to correlate better with the underlying venous saturation than the IDO2 index.
连续监测软件T3有一个名为50%氧输送不足指数（IDO2-50）的综合指标，该指标显示混合静脉血氧饱和度低于用户选择的30%-50%阈值的概率。本研究的主要目的是确定IDO2-50与测量的静脉血氧饱和度之间的相关性。本研究的次要目的是描述导致IDO2-50的血流动力学因素。这项单中心回顾性研究旨在描述IDO2-50与下腔静脉（IVC）血氧饱和度之间的相关性。进行了贝叶斯皮尔逊相关性分析，以评估所收集的感兴趣变量之间的相关性，特别关注IDO2-50与IVC血氧饱和度之间的相关性。采用受试者工作特征曲线（ROC）分析来评估IDO2-50识别静脉血氧饱和度低于50%的能力。以IDO2-50（因变量）和其他自变量进行贝叶斯线性回归。共收集了15例独特患者的113个数据集。IDO2-50与IVC血氧饱和度具有中度相关性（相关系数为-0.569）。IDO2-50与脑近红外光谱（NIRS）值具有弱但显著的相关性，与心率具有弱但显著的相关性，与动脉血氧饱和度具有中度且显著的相关性。ROC分析表明，IDO2-50具有良好的识别静脉血氧饱和度低于50%的能力，曲线下面积为0.797，截断点为24.5，灵敏度为81%，特异度为66%，阳性预测值为44%，阴性预测值为91%。贝叶斯线性回归分析得出以下模型：237.82 +（1.18×月龄）-（3.31×动脉血氧饱和度）-（1.92×脑NIRS）+（0.84×心率）。IDO2指数与IVC血氧饱和度具有中度相关性。它具有良好的敏感性和阴性预测价值。与IDO2指数相比，脑NIRS似乎与潜在的静脉血氧饱和度相关性更好。
