Laboratory of Epidemiology and Population Science National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Clin Transl Med. 2023 Sep;13(9):e1412. doi: 10.1002/ctm2.1412.
Recent data indicate a decline in overall longevity in the United States. Even prior to the COVID-19 pandemic, an increase in midlife mortality rates had been reported. Life expectancy disparities have persisted in the United States for racial and ethnic groups and for individuals living at low socioeconomic status. These continued trends in mortality indicate the importance of examining biomarkers of mortality at midlife in at-risk populations. Circulating levels of cytokines and inflammatory markers reflect systemic chronic inflammation, which is a well-known driver of many age-related diseases.
In this study, we examined the relationship of nine different inflammatory proteins with mortality in a middle-aged socioeconomically diverse cohort of African-American and White men and women (n = 1122; mean age = 47.8 years).
We found significant differences in inflammatory-related protein serum levels between African-American and White middle-aged adults. E-selectin and fibrinogen were significantly higher in African-American adults. IFN-γ, TNF-α trimer, monocyte chemoattractant protein-1 (MCP-1), soluble receptor for advanced glycation end-products (sRAGE) and P-selectin were significantly higher in White participants compared to African-American participants. Higher levels of E-selectin, MCP-1 and P-selectin were associated with a higher mortality risk. Furthermore, there was a significant interaction between sex and IL-6 with mortality. IL-6 levels were associated with an increased risk of mortality, an association that was significantly greater in women than men. In addition, White participants with high levels of sRAGE had significantly higher survival probability than White participants with low levels of sRAGE, while African-American participants had similar survival probabilities across sRAGE levels.
These results suggest that circulating inflammatory markers can be utilized as indicators of midlife mortality risk in a socioeconomically diverse cohort of African-American and White individuals.
最近的数据表明，美国的整体预期寿命有所下降。甚至在 COVID-19 大流行之前，就已经报告中年死亡率有所上升。在美国，种族和族裔群体以及生活在低社会经济地位的个人之间一直存在预期寿命差距。这些持续的死亡率趋势表明，在高危人群中检查中年期死亡生物标志物的重要性。细胞因子和炎症标志物的循环水平反映了全身慢性炎症，这是许多与年龄相关疾病的已知驱动因素。
在这项研究中，我们检查了在一个具有社会经济多样性的非裔美国人和白人中年男女队列（n=1122；平均年龄 47.8 岁）中，9 种不同炎症蛋白与死亡率的关系。
我们发现非裔美国人和白人中年成年人之间的炎症相关蛋白血清水平存在显著差异。E-选择素和纤维蛋白原在非裔美国人中明显更高。IFN-γ、TNF-α三聚体、单核细胞趋化蛋白-1（MCP-1）、可溶性晚期糖基化终产物受体（sRAGE）和 P-选择素在白人参与者中明显高于非裔美国参与者。E-选择素、MCP-1 和 P-选择素水平较高与较高的死亡率风险相关。此外，性别和 IL-6 与死亡率之间存在显著的相互作用。IL-6 水平与死亡率增加的风险相关，这种关联在女性中明显大于男性。此外，高 sRAGE 水平的白人参与者的生存概率明显高于低 sRAGE 水平的白人参与者，而非裔美国参与者的 sRAGE 水平之间的生存概率相似。
这些结果表明，在具有社会经济多样性的非裔美国人和白人个体中，循环炎症标志物可用作中年期死亡率风险的指标。
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