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使用晚期糖基化终末产物可溶性受体（sRAGE）作为疾病风险和不良结局的潜在生物标志物。

The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes.

作者信息

Erusalimsky Jorge D

机构信息

The Cellular Senescence and Pathophysiology Group, Cardiff Metropolitan University, Cardiff, UK.

出版信息

Redox Biol. 2021 Jun;42:101958. doi: 10.1016/j.redox.2021.101958. Epub 2021 Mar 29.

DOI:10.1016/j.redox.2021.101958
PMID:33839083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8113049/
Abstract

The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease. An alternative, though not mutually exclusive view is that high levels of sRAGE in circulation reflect the overstimulation of cell surface RAGE which if persistent, lead to the amplification of pro-inflammatory processes and the exacerbation of pathological states. With these two scenarios in mind this review focuses on the potential role of sRAGE as a prospective biomarker of disease risk and adverse outcomes.

摘要

晚期糖基化终产物可溶性受体（sRAGE）传统上被认为是促炎RAGE配体的一个汇集点，因此与免受炎症应激和疾病的影响有关。另一种观点（尽管并非相互排斥）认为，循环中高水平的sRAGE反映了细胞表面RAGE的过度刺激，如果这种刺激持续存在，会导致促炎过程的放大和病理状态的加剧。考虑到这两种情况，本综述重点关注sRAGE作为疾病风险和不良后果潜在生物标志物的作用。

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2
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Mol Med Rep. 2021 Mar;23(3). doi: 10.3892/mmr.2021.11854. Epub 2021 Jan 26.
3
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Arch Osteoporos. 2025 Aug 27;20(1):116. doi: 10.1007/s11657-025-01554-z.
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