老年人的生存情况：更高的流感抗体滴度具有保护作用吗？
Survival at older ages: are greater influenza antibody titers protective?
作者信息
Metcalf Cje, Klein S L, Read J M, Riley S, Cummings Dat, Guan Yi, Kwok K O, Huachen Z, Jiang C Q, Lam Tai Hing, Lessler J
机构信息
Dept of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
出版信息
Med Hypotheses. 2023 Sep;178. doi: 10.1016/j.mehy.2023.111135. Epub 2023 Aug 10.
Antibodies are a core element of the immune system's defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be modulated by vaccination, these results have important implications for public health policy on influenza control in aging populations.
抗体是免疫系统抵御传染病的核心要素。我们推测，抗体滴度可能因此成为老年个体生存的重要预测指标。这一点很重要，因为尽管在医疗保健环境中有潜在用途，但能可靠衡量生存情况的生物标志物一直难以找到。我们提供证据支持这一假设，即流感抗体滴度与老年个体的总体生存相关，并表明生物性别在调节这种关联中发挥作用。由于抗体滴度可通过接种疫苗来调节，这些结果对老年人群流感防控的公共卫生政策具有重要意义。
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