解析针对 SARS-CoV-2 的抗体介导保护作用。
Dissecting antibody-mediated protection against SARS-CoV-2.
机构信息
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
出版信息
Nat Rev Immunol. 2020 Jul;20(7):392-394. doi: 10.1038/s41577-020-0359-5. Epub 2020 Jun 8.
Understanding the properties and mechanisms by which antibodies provide protection is essential to defining immunity. Although neutralizing antibodies have been proposed as a potential key mechanism of protection against many viral pathogens, antibodies mediate additional immune functions that may have both protective and pathological consequences. Dissecting these properties against SARS-CoV-2 is likely necessary for defining metrics of immunity that will inform the design of vaccines and therapeutics and improve clinical management.
了解抗体提供保护的特性和机制对于确定免疫至关重要。虽然中和抗体已被提议作为许多病毒病原体的潜在关键保护机制，但抗体介导的其他免疫功能可能具有保护和病理后果。对抗 SARS-CoV-2 进行这些特性的剖析可能对于定义免疫指标是必要的，这些指标将为疫苗和治疗药物的设计提供信息，并改善临床管理。
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