Sas M, Godó G, Koloszár S
Acta Med Hung. 1986;43(1):13-22.
A report is given of 87 pregnancies in hyperprolactinaemic women treated with bromocriptine. The high prolactin level in 11 cases was caused by hypophyseal adenoma. If the plasma prolactin level exceeded 5000 mU/l during pregnancy, bromocriptine was administered until delivery. If the initial prolactin value was over 1000 mU/l, the prolactin level was measured during pregnancy, delivery and the lactational period. After weaning, the prolactin level was again elevated in the majority of cases. During pregnancy, delivery and lactation, complications which differed significantly from the usual were not observed, pregnancy and nursing took place normally. Breast feeding was not contraindicated in any of the cases. Among the newborns, adaptation disturbances and congenital malformations, showed the usual frequency. In the authors' opinion pregnancies which occur during the treatment of hyperprolactinaemic patients need increased care. Complications during pregnancy, delivery and nursing period were not more frequently observed either in the mother or the newborn. The hyperprolactinaemic syndrome did not deteriorate during gestation and lactation, but its normalization can not be expected.
报告了87例接受溴隐亭治疗的高泌乳素血症女性的妊娠情况。11例患者的高泌乳素水平由垂体腺瘤引起。如果孕期血浆泌乳素水平超过5000 mU/l，则持续给予溴隐亭直至分娩。如果初始泌乳素值超过1000 mU/l，则在孕期、分娩期及哺乳期测量泌乳素水平。断奶后，大多数病例的泌乳素水平再次升高。在孕期、分娩期及哺乳期，未观察到与通常情况有显著差异的并发症，妊娠及哺乳过程正常。所有病例均未禁忌母乳喂养。在新生儿中，适应障碍和先天性畸形的发生率与通常情况相同。作者认为，高泌乳素血症患者治疗期间发生的妊娠需要加强护理。母亲或新生儿在孕期、分娩期及哺乳期并发症的发生频率并未增加。高泌乳素血症综合征在妊娠和哺乳期并未恶化，但也无法期望其恢复正常。
