Prathibha D, Govardhani M, Krishna P T
Institute of Obstetrics and Gynaecology, Government Maternity Hospital, Hyderabad.
J Indian Med Assoc. 1994 Dec;92(12):397-9.
Serum prolactin levels were estimated in 100 infertile patients along with the other investigations for infertility. Hyperprolactinaemia was noted in 41% of the infertile patients. Prevalence of hyperprolactinaemia was greater in patients with ovulatory cycles ie, 55% compared to 31.66% in patients with anovulatory and oligo-ovulatory cycles. Fifty per cent of the patients with regular menses had hyperprolactinaemia. Conception occurred in 9 out of 18 hyperprolactinaemic infertile patients (a pregnancy rate of 50%) treated with bromocriptine. Eleven patients (group 1) were treated with bromocriptine from day 5 to day 30 throughout the menstrual cycle and 5 conceptions occurred. Six patients (group 2) with ovulatory cycles were treated with bromocriptine during the luteal phase, from the day of ovulation till next menses and 4 conceived. One patient of prolactinoma treated with bromocriptine failed to conceive. Bromocriptine therapy restricted to the luteal phase in ovulatory patients has yielded successful results. Based on these observations it is suggested that all patients of infertility need serum prolactin estimation.
对100例不孕患者进行了血清催乳素水平测定以及其他不孕相关检查。41%的不孕患者存在高催乳素血症。排卵周期患者中高催乳素血症的患病率更高，即55%，而无排卵和稀发排卵周期患者中这一比例为31.66%。月经规律的患者中有50%存在高催乳素血症。18例高催乳素血症不孕患者中9例受孕（妊娠率为50%），这些患者接受了溴隐亭治疗。11例患者（第1组）在整个月经周期的第5天至第30天接受溴隐亭治疗，5例受孕。6例排卵周期患者（第2组）在黄体期，即从排卵日至下次月经期间接受溴隐亭治疗，4例受孕。1例催乳素瘤患者接受溴隐亭治疗后未受孕。排卵患者仅在黄体期进行溴隐亭治疗已取得成功结果。基于这些观察结果，建议所有不孕患者都需要进行血清催乳素测定。
