Qian Li-Hua, Kong Xiang, Zhou Liu-Lin
Clinical Medical College of Yangzhou University, No. 136 Middle Jiangyang Road, Hanjiang District, Yangzhou 225000, China.
Department of Obstetrics and Gynecology, Taixing People's Hospital, No. 1 Changzheng Road, Taixing City, Taizhou 225400, China.
Iran J Public Health. 2023 Aug;52(8):1656-1664. doi: 10.18502/ijph.v52i8.13403.
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, usually occurring in the third trimester of pregnancy. Its typical clinical manifestations are itching and elevated serum total bile acid levels, which are more harmful to the fetus, and can lead to a variety of adverse pregnancy outcomes. This paper discusses the expressions of galectin -1 and 3 in the serum and placenta of ICP patients and their relationship with the effect of the incidence of ICP.
Galectin-1 and 3 in serum and placenta were detected in 22 pregnant women with ICP and 20 healthy pregnant women admitted to the obstetrics Department of Northern Jiangsu People's Hospital from May 2021 to February 2022.
Serum levels of galectin-1 and galectin-3 in ICP pregnant women were significantly higher than those in controls, with significant differences (<0.05). Placental galectin-1 and 3 were higher in normal pregnant women, and there were statistical differences between groups (<0.05).
In ICP, the maternal serum and placental galectin-1 and 3 levels were significantly increased, both of which may play an important role in the development of ICP, which may be the initiation factor of ICP pathophysiology, a marker of ICP prediction, and a target of ICP prevention strategies.
妊娠期肝内胆汁淤积症（ICP）是一种妊娠特有的肝脏疾病，通常发生在妊娠晚期。其典型临床表现为瘙痒和血清总胆汁酸水平升高，对胎儿危害较大，可导致多种不良妊娠结局。本文探讨半乳糖凝集素-1和3在ICP患者血清及胎盘组织中的表达情况及其与ICP发病的关系。
选取2021年5月至2022年2月在苏北人民医院产科住院的22例ICP孕妇和20例正常孕妇，检测其血清及胎盘组织中半乳糖凝集素-1和3的表达水平。
ICP孕妇血清半乳糖凝集素-1和3水平显著高于对照组，差异有统计学意义（<0.05）。正常孕妇胎盘组织中半乳糖凝集素-1和3的表达水平较高，两组比较差异有统计学意义（<0.05）。
ICP患者母体血清及胎盘组织中半乳糖凝集素-1和3水平显著升高，二者可能在ICP发病过程中发挥重要作用，可能是ICP病理生理过程的起始因素、ICP预测的标志物及ICP防治策略的靶点。
