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宫内生长受限（IUGR）病例中半乳糖凝集素-1、半乳糖凝集素-2、半乳糖凝集素-3和半乳糖凝集素-13的胎盘表达模式

Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR).

作者信息

Hutter Stefan, Knabl Julia, Andergassen Ulrich, Hofmann Simone, Kuhn Christina, Mahner Sven, Arck Petra, Jeschke Udo

机构信息

Department of Gynecology and Obstetrics, Ludwig Maximilians University of Munich, Maistraße 11, 80337 Munich, Germany.

Department of Gynecology and Obstetrics, University of Hamburg, Martinistr. 52, 20246 Hamburg, Germany.

出版信息

Int J Mol Sci. 2016 Apr 7;17(4):523. doi: 10.3390/ijms17040523.

DOI:10.3390/ijms17040523
PMID:27070577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4848979/
Abstract

Galectins (gal) are members of the mammalian β-galactoside-binding proteins and recognize Galβ1-4GlcNAc and Galβ1-4GalNac (Thomsen-Friedenreich antigen (TF)) sequences of several cell surface oligosaccharides. In this study, gal-1, -2, -3 and -13 were investigated systematically in the trophoblast and decidua compartment of intrauterine growth restriction (IUGR) placentas and normal third trimester control placentas and stratified by fetal gender and gestational age. Within this study, 29 third trimester placentas after delivery were analyzed. Fetal gender was equally divided within both groups, and immunohistochemical staining was analyzed according to fetal gender and gestational age. Double immune-fluorescence with trophoblast-specific markers was used to identify galectin-expressing cells at the feto-maternal interface in the decidua. Gal-3 was significantly downregulated only in the extravillous trophoblast of IUGR placentas. In contrast, expressions of gal-2 and gal-13 were downregulated in both villous and extravillous trophoblast cells of IUGR placentas. In addition, gal-2 and gal-13 showed a highly correlated expression scheme in the placenta. There are significant gender-specific expression patterns for single prototype galectins with downregulation of gal-2 and gal-13 of male gender placentas in cases of IUGR. Gal-3 as the chimera type galectin shows only little gender-specific differences in expression, which disappear in IUGR cases.

摘要

半乳糖凝集素（gal）是哺乳动物β-半乳糖苷结合蛋白家族成员，可识别几种细胞表面寡糖的Galβ1-4GlcNAc和Galβ1-4GalNac（汤姆森-弗里德赖希抗原（TF））序列。在本研究中，对宫内生长受限（IUGR）胎盘和正常孕晚期对照胎盘的滋养层和蜕膜部分中的gal-1、-2、-3和-13进行了系统研究，并按胎儿性别和孕周进行分层。在这项研究中，分析了29例分娩后的孕晚期胎盘。两组胎儿性别分布均衡，并根据胎儿性别和孕周对免疫组织化学染色进行分析。使用滋养层特异性标记物进行双重免疫荧光，以鉴定蜕膜中胎儿-母体界面处表达半乳糖凝集素的细胞。Gal-3仅在IUGR胎盘的绒毛外滋养层中显著下调。相比之下，IUGR胎盘的绒毛和绒毛外滋养层细胞中gal-2和gal-13的表达均下调。此外，gal-2和gal-13在胎盘中表现出高度相关的表达模式。在IUGR病例中，单个原型半乳糖凝集素存在显著的性别特异性表达模式，男性胎盘的gal-2和gal-13下调。Gal-3作为嵌合型半乳糖凝集素，在表达上仅表现出很小的性别特异性差异，在IUGR病例中这种差异消失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c82/4848979/a7622a327518/ijms-17-00523-g010.jpg
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