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胰腺癌危险因素的病例对照试验：系统评价与Meta分析

Case-Control Trials on Risk Factors for Pancreatic Cancer: A Systematic Review and Meta-Analysis.

作者信息

Yang Yan, Shi Jianwei, Huang Jiaoling, Cheng Mingwang, Geng Shasha, Yu Wenya, Chen Ning, Chen Chen, Wang Zhaoxin

机构信息

School of Economics & Management, Tongji University, Shanghai, China.

School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Iran J Public Health. 2023 Aug;52(8):1578-1588. doi: 10.18502/ijph.v52i8.13397.

DOI:10.18502/ijph.v52i8.13397

PMID:37744539

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10512132/

Abstract

BACKGROUND

The single risk factors of pancreatic cancer (PC) has been extensively studied. We aimed to synthesize results from such studies to identify and estimate multiple independent risk factors of PC.

METHODS

Articles published up to Feb 28, 2020 in English or Chinese reporting risk factors of PC were reviewed. The fixed-effects model with 95% confidence interval (CI) were used to calculate the pooled Odds Ratio (OR). Data were analyzed using RevMan 5.3.

RESULTS

PC was significantly associated with smoking (: 1.76, 95% : 1.61-1.92, < 0.00001, = 6%), diabetes (: 2.69, 95% : 2.52-2.88, < 0.00001, = 0%), family history of PC (: 2.58, 95% : 2.13-3.11, < 0.00001, = 0%), and chronic pancreatitis (: 5.84, 95% : 3.63-9.41, < 0.00001, = 0%).

CONCLUSION

Smoking, diabetes, family history of PC, and chronic pancreatitis were independent risk factors for PC. These independent risk factors have an important role in identifying high-risk groups, which is of great significance to reduce the incidence of PC and improve the quality of life and prognosis of patients.

摘要

背景

胰腺癌（PC）的单一危险因素已得到广泛研究。我们旨在综合这些研究结果，以识别和评估PC的多个独立危险因素。

方法

回顾了截至2020年2月28日发表的中英文报道PC危险因素的文章。采用95%置信区间（CI）的固定效应模型计算合并比值比（OR）。使用RevMan 5.3软件进行数据分析。

结果

PC与吸烟显著相关（：1.76，95%：1.61 - 1.92，< 0.00001，= 6%）、糖尿病（：2.69，95%：2.52 - 2.88，< 0.00001，= 0%）、PC家族史（：2.58，95%：2.13 - 3.11，< 0.00001，= 0%）和慢性胰腺炎（：5.84，95%：3.63 - 9.41，< 0.00001，= 0%）。