Bouali Nouha, Haddaji Najla, Hamadou Walid Sari, Ghorbel Mouna, Bechambi Olfa, Mahdhi Abdelkarim, Snoussi Majdi
Department of Biology, College of Science, University of Ha'il, Ha'il, Saudi Arabia.
Laboratory of Analysis, Treatment and Valorization of Pollutants of the Environment and Products, Faculty of Pharmacy, University of Monastir, Tunisia.
Iran J Public Health. 2023 Aug;52(8):1555-1564. doi: 10.18502/ijph.v52i8.13395.
Over the last decade, we were facing medical struggle by the emergence of multi-resistant bacteria, especially methicillin-resistant (MRSA). MRSA infections are still causing a growing global concern due to the rapid adaptive multidrug resistance to conventional antibiotics in human, community and veterinary medicine. Here we provide an overview about MRSA epidemiology, transmission and alternative potential treatments particularly new discovered phytochemicals with biological activity. In this narrative review, bibliographic data was collected from literature search databases: Google Scholar, web of science and PubMed/MEDLINE during recent years (2016 to 2021). MRSA is responsible of wide spectrum life threatening infections such us septicemia, endocarditis, and wound infections. It has epidemic potential in hospitals, that is responsible of most nosocomial infections leading to mortality and constitute a real burden for the healthcare systems. Effective preventive strategies for management of MRSA are highly required moreover, the identification and development of novel drugs or active biomolecules through phytochemicals are time challenging to face new resistant strains.
在过去十年中，我们一直面临着多重耐药细菌出现带来的医学挑战，尤其是耐甲氧西林金黄色葡萄球菌（MRSA）。由于在人类医学、社区医学和兽医学中，MRSA对传统抗生素迅速产生适应性多重耐药性，其感染仍在全球范围内引起越来越多的关注。在此，我们概述了MRSA的流行病学、传播途径以及替代潜在治疗方法，特别是新发现的具有生物活性的植物化学物质。在这篇叙述性综述中，通过文献搜索数据库（谷歌学术、科学网和PubMed/MEDLINE）收集了近年来（2016年至2021年）的书目数据。MRSA可导致多种危及生命的感染，如败血症、心内膜炎和伤口感染。它在医院具有流行潜力，是导致大多数医院感染并造成死亡的原因，给医疗系统带来了沉重负担。此外，迫切需要有效的MRSA管理预防策略，而且通过植物化学物质鉴定和开发新型药物或活性生物分子以应对新的耐药菌株极具挑战性。
