Alminderej Fahad, Bakari Sana, Almundarij Tariq I, Snoussi Mejdi, Aouadi Kaïss, Kadri Adel
Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia.
Department of Chemistry, Faculty of Science of Sfax, University of Sfax, B.P. 1171, Sfax 3000, Tunisia.
Plants (Basel). 2021 Jan 22;10(2):205. doi: 10.3390/plants10020205.
is an important plant commonly known as cubeb or Java pepper, and it is cultivated for its fruit and essential oils, largely used to treat various diseases. Up to today, there was no scientific report on wound healing activity. Thus, this study was initiated to evaluate for the first time the antimicrobial activity and wound healing potential of a new chemotype from essential oil (PCEO) from fruits. Thirteen microbial strains have been selected to investigate the antimicrobial potential of PCEO. For the evaluation of the wound healing potential, sixteen rats were excised on the dorsal back and divided into four groups. The effect of PCEO on the malondialdehyde (MDA) and superoxide dismutase (SOD) activities in the healed wound area of rats and the biochemical parameters and skin histological analysis were also assessed. Results: Data showed that PCEO exhibited a powerful antimicrobial potential especially against and . In addition, the topical application of PCEO cream appears to increase the SOD level, wound healing and contraction but reduced the MDA amount suggesting an impressive and a rapid cutaneous healing power. Additionally, histopathological analysis of the granulation tissue revealed that the derma is properly restored and arranged after treatment with PCEO. The docking analysis of PCEO constituents against tyrosyl-tRNA synthetase enzyme showed binding energies values in the range of -7.2 to -4.8 kcal/mol. In conclusion, the topic use of PCEO healing cream showed significant effect in accelerating the healing process, which may be attributed to the synergetic effect of antioxidant and antimicrobial properties of PCEO volatile constituents, making it a relevant therapeutic agent for the management of wounds and therefore confirming the popular traditional uses of this plant.
是一种重要的植物，通常被称为荜澄茄或爪哇胡椒，其果实和精油可供种植，主要用于治疗各种疾病。到目前为止，尚无关于其伤口愈合活性的科学报道。因此，本研究首次开展，旨在评估一种来自果实精油（PCEO）的新化学型的抗菌活性和伤口愈合潜力。已选择13种微生物菌株来研究PCEO的抗菌潜力。为评估伤口愈合潜力，对16只大鼠背部进行切除并分为四组。还评估了PCEO对大鼠愈合伤口区域丙二醛（MDA）和超氧化物歧化酶（SOD）活性的影响以及生化参数和皮肤组织学分析。结果：数据显示PCEO具有强大的抗菌潜力，尤其是对[具体菌种1]和[具体菌种2]。此外，局部应用PCEO乳膏似乎可提高SOD水平、促进伤口愈合和收缩，但可降低MDA含量，表明其具有令人印象深刻的快速皮肤愈合能力。此外，对肉芽组织的组织病理学分析显示，用PCEO治疗后真皮得到适当恢复和排列。PCEO成分与酪氨酰 - tRNA合成酶的对接分析显示结合能值在 - 7.2至 - 4.8千卡/摩尔范围内。总之，局部使用PCEO愈合乳膏在加速愈合过程中显示出显著效果，这可能归因于PCEO挥发性成分的抗氧化和抗菌特性的协同作用，使其成为治疗伤口的相关治疗剂，从而证实了这种植物在传统医学中的广泛应用。
