Alterations in and are associated with the localization of contrast-enhancing lesions in glioblastoma.

BACKGROUND

Glioblastoma (GBM) is a malignant brain tumor, with radiological and genetic heterogeneity. We examined the association between radiological characteristics and driver gene alterations.

METHODS

We analyzed the driver genes of 124 patients with wild-type GBM with contrast enhancement using magnetic resonance imaging. We used a next-generation sequencing panel to identify mutations in driver genes and matched them with radiological information. Contrast-enhancing lesion localization of GBMs was classified into 4 groups based on their relationship with the subventricular zone (SVZ) and cortex (Ctx).

RESULTS

The cohort included 69 men (55.6%) and 55 women (44.4%) with a mean age of 66.4 ± 13.3 years. and alterations were detected in 28.2% and 22.6% of the patients, respectively. Contrast-enhancing lesion touching both the SVZ and Ctx was excluded because it was difficult to determine whether it originated from the SVZ or Ctx. Contrast-enhancing lesions touching the SVZ but not the Ctx had significantly worse overall survival than non-SVZ lesions (441 days vs. 897 days,  = .002). GBM touching only the Ctx had a better prognosis (901 days vs. 473 days,  < .001) than non-Ctx lesions and was associated with alteration (39.4% vs. 13.2%,  = .015). Multiple contrast lesions were predominant in alteration and -wild type ( = .036 and  = .031, respectively).

CONCLUSIONS

alteration was associated with cortical lesions. And alteration correlated with multiple lesions. Our results suggest that clarifying the association between driver genes and tumor localization may be useful in clinical practice, including prognosis prediction.