Mori Tomotaka, Ozawa Eisuke, Shimakura Akane, Takahashi Kosuke, Matsuo Satoshi, Tajima Kazuaki, Nakao Yasuhiko, Fukushima Masanori, Sasaki Ryu, Miuma Satoshi, Miyaaki Hisamitsu, Okano Shinji, Nakao Kazuhiko
Department of Gastroenterology and Hepatology Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan.
Department of Pathology Nagasaki University Hospital Nagasaki Japan.
JGH Open. 2023 Sep 7;7(9):652-658. doi: 10.1002/jgh3.12965. eCollection 2023 Sep.
Reports have indicated that a surface area of 4 mm or more of collected tissue sections could provide the recommended total DNA for the OncoGuide NCC Oncopanel system, which is a cancer gene panel test developed in Japan. We wished to compare the percentage of tissue sections collected by endoscopic ultrasound-assisted tissue acquisition (EUS-TA) with surface areas of ≥4 mm between a conventional needle, namely the EZ Shot 3 Plus (Olympus Medical Japan, Tokyo, Japan) (EZ3), and the recent SonoTip TopGain (MediGlobe, Rohrdorf, Germany) (TopGain).
From April 2010 to December 2021, among 693 EUS-TA cases, EZ3 was used in 390 cases and TopGain in 45. The EZ3 and TopGain groups were matched in a 1:1 ratio with a tolerance of 0.2, with 35 patients each matched using propensity score analysis.
The TopGain group had a significantly higher percentage of cases with a tissue area of ≥4 mm than the EZ3 group (42.9% 68.6%, = 0.030). Multivariate analysis revealed an association between TopGain and tissue areas of ≥4 mm (odds ratio 2.996, 95% confidence interval 1.068-8.403, = 0.037).
EUS-TA using TopGain significantly collected more ≥4 mm tissue area compared with EZ3, suggesting its usefulness for cancer gene panel testing.
有报告指出，对于日本研发的癌症基因检测板系统OncoGuide NCC Oncopanel而言，收集的组织切片表面积达到4毫米或更大时，可提供推荐的总DNA量。我们希望比较内镜超声引导下组织获取术（EUS-TA）所收集的组织切片中，表面积≥4毫米的切片所占百分比，比较对象为传统穿刺针即EZ Shot 3 Plus（日本东京奥林巴斯医疗株式会社）（EZ3）与最新的SonoTip TopGain（德国罗德多夫MediGlobe公司）（TopGain）。
2010年4月至2021年12月期间，在693例EUS-TA病例中，390例使用了EZ3，45例使用了TopGain。EZ3组和TopGain组以1:1的比例进行匹配，允许误差为0.2，通过倾向得分分析每组各匹配35例患者。
TopGain组中组织面积≥4毫米的病例百分比显著高于EZ3组（42.9%对68.6%，P = 0.030）。多因素分析显示TopGain与组织面积≥4毫米之间存在关联（优势比2.996，95%置信区间1.068 - 8.403，P = 0.037）。
与EZ3相比，使用TopGain进行EUS-TA显著收集到更多面积≥4毫米的组织，表明其在癌症基因检测板检测中具有实用性。
