Oezkan Filiz, Byun Woo Yul, Loeffler Clemens, Siebolts Udo, Diessel Linda, Lambrecht Nina, Eisenmann Stephan
Comprehensive Cancer Center, Division of Medical Oncology, The Ohio State University, Columbus, OH 43210, USA.
Fifth Department of Medicine, University Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
J Clin Med. 2021 Dec 29;11(1):163. doi: 10.3390/jcm11010163.
Advancements in personalized medicine have increased the demand for quantity and preservation of tissue architecture of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples. These demands may be addressed by the SonoTip TopGain needle, which has a 3-point crown-cut design that contrasts with the standard single bevel design of the ViziShot 2. The objective was to compare the SonoTip TopGain and ViziShot 2 needles by considering biopsy sample characteristics, diagnostic accuracy, and patient safety. The primary endpoint of the study was the number of high-power fields (HPFs) in the center of the formalin-fixed paraffin-embedded cell block per sample. The lymph node with the highest probability for malignant infiltration based on size and sonographic appearance was chosen as the target lymph node for 20 patients. The same lymph node in each patient was sampled using both the ViziShot 2 and SonoTip TopGain needles. The samples were measured, sliced, and analyzed by a pathologist. Sixteen patients were biopsied with both needles. Four patients could not be biopsied with the SonoTip TopGain needle since it could not penetrate cartilage or be repositioned to bypass cartilage. HPFs and sample dimensions were significantly greater in the patients where sampling with the SonoTip TopGain needle was possible ( = 0.007 and = 0.005, respectively). Diagnostic accuracy and safety profiles were comparable. Significantly more material can be sampled using the SonoTip TopGain needle when cartilage penetration can be avoided. This improves the yield for molecular workup in the era of personalized medicine.
个性化医疗的进步增加了对支气管内超声引导经支气管针吸活检（EBUS-TBNA）样本数量和组织结构保存的需求。SonoTip TopGain针或许可以满足这些需求，它采用三点冠状切割设计，与ViziShot 2的标准单斜面设计不同。目的是通过考虑活检样本特征、诊断准确性和患者安全性来比较SonoTip TopGain针和ViziShot 2针。该研究的主要终点是每个样本在福尔马林固定石蜡包埋细胞块中心的高倍视野（HPF）数量。根据大小和超声表现，选择恶性浸润可能性最高的淋巴结作为20例患者的目标淋巴结。对每位患者的同一个淋巴结分别使用ViziShot 2针和SonoTip TopGain针进行采样。样本由病理学家进行测量、切片和分析。16例患者用两种针都进行了活检。4例患者无法使用SonoTip TopGain针进行活检，因为它无法穿透软骨或重新定位以绕过软骨。在可以使用SonoTip TopGain针采样的患者中，HPF和样本尺寸显著更大（分别为 = 0.007和 = 0.005）。诊断准确性和安全性相当。当可以避免穿透软骨时，使用SonoTip TopGain针可以获取显著更多的样本材料。这提高了个性化医疗时代分子检测的样本量。
