Arishi Roaa A, Lai Ching T, Geddes Donna T, Stinson Lisa F
School of Molecular Sciences, The University of Western Australia, Perth, WA, Australia.
Ministry of Health, Riyadh, Saudi Arabia.
Front Microbiol. 2023 Sep 7;14:1236601. doi: 10.3389/fmicb.2023.1236601. eCollection 2023.
The oral cavity is home to the second most diverse microbiome in the human body. This community contributes to both oral and systemic health. Acquisition and development of the oral microbiome is a dynamic process that occurs over early life; however, data regarding longitudinal assembly of the infant oral microbiome is scarce. While numerous factors have been associated with the composition of the infant oral microbiome, early feeding practices (breastfeeding and the introduction of solids) appear to be the strongest determinants of the infant oral microbiome. In the present review, we draw together data on the maternal, infant, and environmental factors linked to the composition of the infant oral microbiome, with a focus on early nutrition. Given evidence that breastfeeding powerfully shapes the infant oral microbiome, the review explores potential mechanisms through which human milk components, including microbes, metabolites, oligosaccharides, and antimicrobial proteins, may interact with and shape the infant oral microbiome. Infancy is a unique period for the oral microbiome. By enhancing our understanding of oral microbiome assembly in early life, we may better support both oral and systemic health throughout the lifespan.
口腔是人体中微生物群落第二丰富的部位。这个群落对口腔健康和全身健康都有影响。口腔微生物群的获得和发展是一个在生命早期发生的动态过程；然而，关于婴儿口腔微生物群纵向组装的数据却很稀少。虽然有许多因素与婴儿口腔微生物群的组成有关，但早期喂养方式（母乳喂养和固体食物的引入）似乎是婴儿口腔微生物群最强的决定因素。在本综述中，我们汇总了与婴儿口腔微生物群组成相关的母体、婴儿和环境因素的数据，重点关注早期营养。鉴于有证据表明母乳喂养对婴儿口腔微生物群有强大的塑造作用，本综述探讨了母乳成分（包括微生物、代谢物、低聚糖和抗菌蛋白）可能与婴儿口腔微生物群相互作用并对其进行塑造的潜在机制。婴儿期是口腔微生物群的一个独特时期。通过加强我们对生命早期口腔微生物群组装的理解，我们可以在整个生命周期中更好地支持口腔健康和全身健康。
