Mainas Giuseppe, Nibali Luigi, Ide Mark, Mahmeed Wael Al, Al-Rasadi Khalid, Al-Alawi Kamila, Banach Maciej, Banerjee Yajnavalka, Ceriello Antonio, Cesur Mustafa, Cosentino Francesco, Firenze Alberto, Galia Massimo, Goh Su-Yen, Janež Andrej, Kalra Sanjay, Kapoor Nitin, Kempler Peter, Lessan Nader, Lotufo Paulo, Papanas Nikolaos, Rizvi Ali A, Sahebkar Amirhossein, Santos Raul D, Stoian Anca P, Toth Peter P, Viswanathan Vijay, Rizzo Manfredi
Periodontology Unit, Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London SE1 9RT, UK.
Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi P.O. Box 112412, United Arab Emirates.
Metabolites. 2022 Dec 26;13(1):40. doi: 10.3390/metabo13010040.
Periodontitis is a microbially driven, host-mediated disease that leads to loss of periodontal attachment and resorption of bone. It is associated with the elevation of systemic inflammatory markers and with the presence of systemic comorbidities. Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the majority of patients have mild symptoms, others experience important complications that can lead to death. After the spread of the COVID-19 pandemic, several investigations demonstrating the possible relationship between periodontitis and COVID-19 have been reported. In addition, both periodontal disease and COVID-19 seem to provoke and/or impair several cardiometabolic complications such as cardiovascular disease, type 2 diabetes, metabolic syndrome, dyslipidemia, insulin resistance, obesity, non-alcoholic fatty liver disease, and neurological and neuropsychiatric complications. Therefore, due to the increasing number of investigations focusing on the periodontitis-COVID-19 relationship and considering the severe complications that such an association might cause, this review aims to summarize all existing emerging evidence regarding the link between the periodontitis-COVID-19 axis and consequent cardiometabolic impairments.
牙周炎是一种由微生物驱动、宿主介导的疾病，会导致牙周附着丧失和骨质吸收。它与全身炎症标志物升高以及全身合并症的存在有关。2019冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的一种传染病。虽然大多数患者症状较轻，但其他患者会出现可能导致死亡的重要并发症。在COVID-19大流行传播之后，已有多项研究报告了牙周炎与COVID-19之间可能存在的关系。此外，牙周疾病和COVID-19似乎都会引发和/或损害多种心脏代谢并发症，如心血管疾病、2型糖尿病、代谢综合征、血脂异常、胰岛素抵抗、肥胖症、非酒精性脂肪性肝病，以及神经和神经精神并发症。因此，鉴于关注牙周炎与COVID-19关系的研究数量不断增加，并考虑到这种关联可能导致的严重并发症，本综述旨在总结关于牙周炎-COVID-19轴之间的联系以及随之而来的心脏代谢损害的所有现有新证据。
