Kozakowski Jarosław, Dudek Piotr, Zgliczyński Wojciech
Department of Endocrinology, Centre of Postgraduate Medical Education, Bielanski Hospital, Warsaw, Poland.
Reumatologia. 2023;61(4):318-325. doi: 10.5114/reum/170401. Epub 2023 Aug 31.
Obesity is a chronic disease that leads to the development of secondary metabolic disturbances and diseases and strongly contributes to increased morbidity and mortality. On the other hand, musculoskeletal disorders are currently the main cause of disability and the second most frequent reason for visits to the doctor. Many studies clearly show that excessive body weight adversely affects the course of almost all musculoskeletal system diseases, from osteoarthritis, through metabolic, systemic connective tissue, to rarely diagnosed diseases. The impact of increased fat mass on the musculoskeletal system is presumably complex in nature and involves the influence of biomechanical, dietary, genetic, inflammatory and metabolic factors. Due to the epidemic nature of obesity and its serious health consequences, this disease requires energetic treatment. It is always based on lifestyle modification enriched, if necessary, by pharmacological and, in justified cases, surgical treatment.
肥胖是一种慢性疾病，会导致继发性代谢紊乱和疾病的发生，并极大地增加发病率和死亡率。另一方面，肌肉骨骼疾病是目前导致残疾的主要原因，也是就医的第二大常见原因。许多研究清楚地表明，超重会对几乎所有肌肉骨骼系统疾病的病程产生不利影响，从骨关节炎到代谢性、全身性结缔组织疾病，再到罕见病。脂肪量增加对肌肉骨骼系统的影响可能本质上很复杂，涉及生物力学、饮食、遗传、炎症和代谢因素的影响。由于肥胖的流行性质及其严重的健康后果，这种疾病需要积极治疗。治疗总是基于生活方式的改变，必要时辅以药物治疗，在合理的情况下还可进行手术治疗。
