Department of IQ Healthcare, Radboudumc, Nijmegen, Netherlands
Department of IQ Healthcare, Radboudumc, Nijmegen, Netherlands.
RMD Open. 2021 Jan;7(1). doi: 10.1136/rmdopen-2020-001498.
Obesity is very common in patients with inflammatory rheumatic diseases (IRDs), of which between 27% and 37% of patients have a body mass index ≥30 kg/m In addition to further increasing the risk of developing cardiovascular diseases (CVDs) in this group of patients, obesity is associated with higher disease activity and a lower response to drug therapy. This case series showed that in those patients with rheumatoid arthritis or psoriatic arthritis with a substantial weight loss of >10% of body mass, median Disease Activity Score 28 joints score decreased with 0.9. This reduction in disease activity resulted in an increase in the percentage of patients achieving remission from 6% to 63%. This reduction in disease activity was obtained without intensification of medical treatment in 87% of the patients. This case series supports the current evidence that weight reduction has positive effects on the course of the disease and thus also on the CVD risk profile in these patients. Therefore, weight loss can serve as a non-pharmacological treatment option in obese patients with IRDs.
肥胖在炎症性风湿病（IRDs）患者中非常常见，其中 27%至 37%的患者体重指数≥30 kg/m2。肥胖除了进一步增加这群患者患心血管疾病（CVDs）的风险外，还与更高的疾病活动度和对药物治疗的反应降低有关。本病例系列研究表明，在那些患有类风湿关节炎或银屑病关节炎且体重减轻超过 10%的患者中，28 关节疾病活动评分中位数下降了 0.9。这种疾病活动度的降低导致缓解的患者比例从 6%增加到 63%。在 87%的患者中，这种疾病活动度的降低是在不强化药物治疗的情况下获得的。本病例系列研究支持目前的证据，即减轻体重对疾病过程有积极影响，从而也对这些患者的 CVD 风险状况有积极影响。因此，体重减轻可以作为肥胖的炎症性风湿病患者的一种非药物治疗选择。
