Yamauchi Satoshi, Sartiva Hazna, Nishiwaki Hisashi
Graduate School of Agriculture, Ehime University.
J Pestic Sci. 2023 Aug 20;48(3):93-98. doi: 10.1584/jpestics.D23-016.
Derivatives of the coumarin ring in ()-3-[3-(4-methoxyphenyl)-1-hydroxyprop-2-yl]coumarin , which is a lignan structure, were synthesized to clarify their structure-phytotoxicity relationships. The growth-inhibitory activity of the 8-OCH derivative (IC=228 µM) was more potent against the roots of lettuce seedlings than the compound without substituents . As for the roots of Italian ryegrass seedlings, the presence of the methoxy group at the 7- or 8-position was extremely effective for inhibiting growth (7-OCH : IC=121 µM, 8-OCH : 56.7 µM). Methyl derivatives at the 5- or 8-position showed activity levels similar to those of the compound without substituents (5-CH : IC=214 µM, 8-CH : IC=225 µM). The activities of OH- and F-derivatives were not observed or were lower.
（）-3-[3-（4-甲氧基苯基）-1-羟基丙-2-基]香豆素（一种木脂素结构）的香豆素环衍生物被合成出来，以阐明其结构与植物毒性之间的关系。8-OCH衍生物（IC = 228 µM）对生菜幼苗根的生长抑制活性比无取代基的化合物更强。至于意大利黑麦草幼苗的根，7-或8-位存在甲氧基对抑制生长极为有效（7-OCH：IC = 121 µM，8-OCH：56.7 µM）。5-或8-位的甲基衍生物显示出与无取代基化合物相似的活性水平（5-CH：IC = 214 µM，8-CH：IC = 225 µM）。未观察到OH-和F-衍生物的活性，或者其活性较低。
