Ambati Vidya L, Cummings Tammy H, Yerramothu Praveen, Nguyen Joseph, Sutton S Scott, Werner Brian C, Magagnoli Joseph
Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, Virginia.
Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, Virginia.
medRxiv. 2023 Sep 12:2023.09.11.23295367. doi: 10.1101/2023.09.11.23295367.
Haloperidol is an anti-psychotic used for the treatment of schizophrenia or Tourette disorder. Here we report, by studying three large administrative health insurance databases, that haloperidol use is associated with a reduced risk of developing rheumatoid arthritis. A meta-analysis revealed a 31% reduced hazard of incident rheumatoid arthritis among individuals with schizophrenia or Tourette disorder treated with haloperidol compared to those treated with other anti-psychotic drugs. These findings suggest a potential benefit of haloperidol in rheumatoid arthritis and provide a rationale for randomized controlled trials to provide causal insights.
氟哌啶醇是一种用于治疗精神分裂症或妥瑞氏症的抗精神病药物。在此，我们通过研究三个大型行政医疗保险数据库报告称，使用氟哌啶醇与患类风湿性关节炎风险降低相关。一项荟萃分析显示，与使用其他抗精神病药物治疗的个体相比，使用氟哌啶醇治疗的精神分裂症或妥瑞氏症患者发生类风湿性关节炎的风险降低了31%。这些发现表明氟哌啶醇在类风湿性关节炎方面具有潜在益处，并为进行随机对照试验以提供因果关系见解提供了理论依据。
