Santos João Paulo Lima, Hayes Rebecca, Franzen Peter L, Goldstein Tina R, Hasler Brant P, Buysse Daniel J, Siegle Greg J, Dahl Ronald E, Forbes Erika E, Ladouceur Cecile D, McMakin Dana L, Ryan Neal D, Silk Jennifer S, Jalbrzikowski Maria, Soehner Adriane M
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
bioRxiv. 2023 Sep 16:2023.09.15.557966. doi: 10.1101/2023.09.15.557966.
Healthy sleep is important for adolescent neurodevelopment, and relationships between brain structure and sleep can vary in strength over this maturational window. Although cortical gyrification is increasingly considered a useful index for understanding cognitive and emotional outcomes in adolescence, and sleep is also a strong predictor of such outcomes, we know relatively little about associations between cortical gyrification and sleep.
Using Local gyrification index (lGI) of 34 bilateral brain regions and regularized regression for feature selection, we examined gyrification-sleep relationships in the Neuroimaging and Pediatric Sleep databank (252 participants; 9-26 years; 58.3% female) and identified developmentally invariant (stable across age) or developmentally specific (observed only during discrete age intervals) brain-sleep associations. Naturalistic sleep characteristics (duration, timing, continuity, and regularity) were estimated from wrist actigraphy.
For most brain regions, greater lGI was associated with longer sleep duration, earlier sleep timing, lower variability in sleep regularity, and shorter time awake after sleep onset. lGI in frontoparietal network regions showed associations with sleep patterns that were stable across age. However, in default mode network regions, lGI was only associated with sleep patterns from late childhood through early-to-mid adolescence, a period of vulnerability for mental health disorders.
We detected both developmentally invariant and developmentally specific ties between local gyrification and naturalistic sleep patterns. Default mode network regions may be particularly susceptible to interventions promoting more optimal sleep during childhood and adolescence.
健康睡眠对青少年神经发育至关重要，在此成熟阶段，大脑结构与睡眠之间的关系强度可能会有所不同。尽管皮质脑回化越来越被认为是理解青少年认知和情绪结果的有用指标，并且睡眠也是这些结果的有力预测因素，但我们对皮质脑回化与睡眠之间的关联了解相对较少。
我们使用34个双侧脑区的局部脑回化指数（lGI）和用于特征选择的正则化回归，在神经影像与儿科睡眠数据库（252名参与者；9 - 26岁；58.3%为女性）中研究脑回化与睡眠的关系，并确定发育不变（跨年龄稳定）或发育特异性（仅在特定年龄间隔观察到）的脑 - 睡眠关联。通过手腕活动记录仪估计自然睡眠特征（持续时间、时间、连续性和规律性）。
对于大多数脑区，较高的lGI与较长的睡眠时间、较早的入睡时间、较低的睡眠规律性变异性以及睡眠开始后较短的清醒时间相关。额顶叶网络区域的lGI与跨年龄稳定的睡眠模式相关。然而，在默认模式网络区域，lGI仅与儿童晚期到青少年早期至中期的睡眠模式相关，这是一个心理健康障碍的易患期。
我们检测到局部脑回化与自然睡眠模式之间存在发育不变和发育特异性的联系。默认模式网络区域可能特别容易受到促进儿童和青少年更优质睡眠的干预措施的影响。
