Maheshwari Yashika, Handa Uma, Aggarwal Phiza, Goel Bharti
Department of Pathology, Govt. Medical College and Hospital, Chandigarh, India.
Department of Obstetrics and Gynecology, Govt. Medical College and Hospital, Chandigarh, India.
J Cytol. 2023 Jul-Sep;40(3):114-118. doi: 10.4103/joc.joc_29_23. Epub 2023 Aug 14.
The conventional smears (CS) and Liquid based cytology (LBC) are important tools to detect carcinoma cervix and its precursor lesions.
The present study was done to compare the cytomorphological features of cervical lesions using both techniques and compare with the histopathological diagnosis.
This was a prospective observational study over a period of 1.5 years at a tertiary care hospital.
A total of 969 women in the age group of 21-65 years presenting with either routine screening or complaints of vaginal bleeding, discharge, or pelvic pain were enrolled for the study. Both the CS and LBC smears were analyzed and compared with the corresponding histopathology diagnosis. The data was analyzed using Statistical Package for the Social Sciences (SPSS) software and values <0.05 were considered significant.
There were 8.57% unsatisfactory smears in CS as compared to 0.5% in LBC smears. Liquid-based cytology was superior to conventional preparations in terms of smear adequacy, lesser hemorrhagic and inflammatory background, and presence of more endocervical cells. Liquid-based cytology showed a better yield in detecting all the types of epithelial cell lesions with a concordance rate of 73.9% between the two techniques. On histopathology correlation of these lesions, LBC had a higher sensitivity (96.67%) and diagnostic accuracy (99.08%) as compared to CS (73.33% and 92.66%, respectively).
Liquid-based cytology is superior to conventional cytology for the detection of epithelial cell lesions. Reduction in the unsatisfactory smears, a cleaner background, and better representation of the sample are more significantly appreciated on LBC in contrast to CS.
传统涂片（CS）和液基细胞学检查（LBC）是检测宫颈癌及其前驱病变的重要工具。
本研究旨在比较使用这两种技术的宫颈病变的细胞形态学特征，并与组织病理学诊断进行比较。
这是一项在三级护理医院进行的为期1.5年的前瞻性观察研究。
共有969名年龄在21 - 65岁之间、因常规筛查或出现阴道出血、分泌物异常或盆腔疼痛等症状而就诊的女性纳入本研究。对CS和LBC涂片均进行分析，并与相应的组织病理学诊断结果进行比较。使用社会科学统计软件包（SPSS）对数据进行分析，P值<0.05被认为具有统计学意义。
CS涂片的不满意率为8.57%，而LBC涂片为0.5%。在涂片充分性、较少的出血和炎症背景以及更多宫颈管内细胞的存在方面，液基细胞学优于传统涂片。液基细胞学在检测所有类型的上皮细胞病变方面表现出更高的检出率，两种技术之间的一致性率为73.9%。在这些病变的组织病理学相关性方面，与CS（分别为73.33%和92.66%）相比，LBC具有更高的敏感性（96.67%）和诊断准确性（99.08%）。
液基细胞学在检测上皮细胞病变方面优于传统细胞学。与CS相比，LBC涂片不满意率降低、背景更清晰以及样本代表性更好，这些优势更为明显。
