Patel Nirali, Bavikar Rupali, Buch Archana, Kulkarni Mayuri, Dharwadkar Arpana, Viswanathan Vidya
Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Gynecol Minim Invasive Ther. 2023 May 18;12(2):77-82. doi: 10.4103/gmit.gmit_118_22. eCollection 2023 Apr-Jun.
Early diagnosis and treatment of preinvasive lesions have made cervical cytology one of the most effective methods of cancer screening in industrialized nations, which have seen a sharp decline in the incidence and death of invasive cancer. The aim of this study is to compare liquid-based cytology (LBC) and conventional Pap on cervical smears.
From July 2018 to June 2022, 600 patients were included in this cross-sectional study, which was done at the Pathology Department of a Tertiary Care Facility in Western Maharashtra.
Of the 600 patients, 570 (95%) had good conventional Pap smear (CPS), whereas 30 (5%) had poor ones. Five hundred and ninety-two (98.6%) LBC smears were satisfactory, whereas 8 (1.4%) were unsatisfactory. Endocervical cells were seen in 294 (49%) CPS, whereas 360 (60%) LBC smears showed endocervical cells. The morphology of inflammatory cells was similar in both techniques. Hemorrhagic background was seen in 212 (35%) CPS and 76 (12.6%) LBC smears. Only two samples showed diathetic background, which was seen on both CPS and smear. Out of the satisfactory smears in the case of CPS, 512 (85%) cases were reported as negative for intraepithelial lesion or malignancy (NILM), whereas 58 (9.7%) cases were reported as epithelial cell abnormality. In LBC smears, 526 (87.3%) were reported as NILM, whereas 66 (11%) were reported as epithelial cell abnormality. Organisms were detected in 208 (34%) CPS and 162 (27%) LBC smears. Screening time was 5 ± 1 min for CPS, whereas it was 3 ± 1 min for LBC smear.
Mortality will be decreased using LBC on a bigger scale in nations where many smears can be made and screened in a short amount of time, with the provision of doing human papillomavirus-based testing on the remaining sample.
对癌前病变进行早期诊断和治疗，使宫颈细胞学检查成为工业化国家最有效的癌症筛查方法之一，这些国家浸润性癌症的发病率和死亡率已大幅下降。本研究的目的是比较宫颈涂片上的液基细胞学检查（LBC）和传统巴氏涂片检查。
2018年7月至2022年6月，本横断面研究纳入了600例患者，研究在西马哈拉施特拉邦一家三级护理机构的病理科进行。
600例患者中，570例（95%）传统巴氏涂片（CPS）质量良好，而30例（5%）质量较差。592例（98.6%）LBC涂片结果满意，而8例（1.4%）不满意。294例（49%）CPS可见宫颈管细胞，而360例（60%）LBC涂片可见宫颈管细胞。两种技术中炎症细胞的形态相似。212例（35%）CPS和76例（12.6%）LBC涂片可见出血背景。只有两个样本显示素质背景，在CPS和涂片上均可见。在CPS的满意涂片中，512例（85%）报告为上皮内病变或恶性肿瘤阴性（NILM），而58例（9.7%）报告为上皮细胞异常。在LBC涂片中，526例（87.3%）报告为NILM，而66例（11%）报告为上皮细胞异常。208例（34%）CPS和162例（27%）LBC涂片检测到微生物。CPS的筛查时间为5±1分钟，而LBC涂片为3±1分钟。
在能够在短时间内进行大量涂片并筛查的国家，大规模使用LBC并对剩余样本进行基于人乳头瘤病毒的检测，将降低死亡率。
