Ellena Valeria, Steiger Matthias G
Austrian Centre of Industrial Biotechnology (ACIB GmbH), Vienna, Austria.
Institute of Chemical, Environmental and Bioscience Engineering, Vienna University of Technology (TU Wien), Vienna, Austria.
Front Fungal Biol. 2022 Jul 15;3:935993. doi: 10.3389/ffunb.2022.935993. eCollection 2022.
The possibility to sequence the entire genome of an organism revolutionized the fields of biology and biotechnology. The first genome sequence of the important filamentous fungus was obtained in 2007, 11 years after the release of the first eukaryotic genome sequence. From that moment, genomics of has seen major progresses, facilitated by the advances in the sequencing technologies and in the methodologies for gene function prediction. However, there are still challenges to face when trying to obtain complete genomes, equipped with all the repetitive sequences that they contain and without omitting the mitochondrial sequences. The aim of this perspective article is to discuss the current status of genomics and draw attention to the open challenges that the fungal community should address to move research of this important fungus forward.
对生物体的全基因组进行测序的可能性彻底改变了生物学和生物技术领域。重要丝状真菌的首个基因组序列于2007年获得，此时距离首个真核生物基因组序列发布已有11年。从那时起，得益于测序技术和基因功能预测方法的进步，该真菌的基因组学取得了重大进展。然而，在试图获得完整基因组时，仍面临挑战，即要包含其所有重复序列且不遗漏线粒体序列。这篇观点文章的目的是讨论该真菌基因组学的现状，并提请关注真菌学界为推动对这种重要真菌的研究而应解决的开放性挑战。
