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氨甲环酸在减少血管外科手术患者围手术期出血和输血需求方面的最佳剂量和给药时间：一项系统评价

The Optimal Dosing and Timing of Tranexamic Acid in Reducing Perioperative Bleeding and Transfusion Requirements in Vascular Surgery Patients: A Systematic Review.

作者信息

Turaga Anjani H

机构信息

Medicine and Surgery, Gandhi Medical College, Hyderabad, IND.

出版信息

Cureus. 2023 Aug 22;15(8):e43947. doi: 10.7759/cureus.43947. eCollection 2023 Aug.

DOI:10.7759/cureus.43947
PMID:37746423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10516444/
Abstract

Tranexamic acid (TXA) has been widely investigated as an antifibrinolytic agent to minimize perioperative bleeding and transfusion requirements in various surgical settings. This systematic review aims to assess the optimal dosing and timing of TXA administration for reducing perioperative bleeding and transfusion requirements, specifically in vascular surgery patients. A comprehensive search was conducted using multiple databases, and relevant articles were selected based on predefined inclusion criteria. A total of 20 studies were identified and analyzed, including randomized controlled trials (RCTs), systematic reviews, and meta-analyses. Findings from these studies were synthesized to provide a comprehensive overview of the evidence regarding the use of TXA in vascular surgery.

摘要

氨甲环酸（TXA）作为一种抗纤溶药物已被广泛研究，以尽量减少各种手术环境下的围手术期出血和输血需求。本系统评价旨在评估TXA给药的最佳剂量和时机，以减少围手术期出血和输血需求，特别是在血管外科患者中。使用多个数据库进行了全面检索，并根据预先定义的纳入标准选择了相关文章。共识别并分析了20项研究，包括随机对照试验（RCT）、系统评价和荟萃分析。综合这些研究的结果，以全面概述关于TXA在血管外科中应用的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6345/10516444/9c1f16b3e8fd/cureus-0015-00000043947-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6345/10516444/9c1f16b3e8fd/cureus-0015-00000043947-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6345/10516444/9c1f16b3e8fd/cureus-0015-00000043947-i01.jpg

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World Neurosurg. 2022 Oct;166:e443-e450. doi: 10.1016/j.wneu.2022.07.020. Epub 2022 Jul 15.
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The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.《PRISMA 2020声明：报告系统评价的更新指南》
Syst Rev. 2021 Mar 29;10(1):89. doi: 10.1186/s13643-021-01626-4.
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Tranexamic acid in cardiac surgery: a systematic review and meta-analysis (protocol).
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BMJ Open. 2019 Sep 17;9(9):e028585. doi: 10.1136/bmjopen-2018-028585.
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BMC Musculoskelet Disord. 2019 Aug 31;20(1):390. doi: 10.1186/s12891-019-2762-2.
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Thromb Res. 2019 Apr;176:61-66. doi: 10.1016/j.thromres.2019.02.006. Epub 2019 Feb 11.
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