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成人尿道下裂修复的患者观点与治疗结果

Patient Perspectives and Outcomes in Adult Hypospadias Repair.

作者信息

Arya Mukesh Chandra, Singh Rambir, Moharjal Pranjal, Gupta Prashant, Singhal Ankur, Mittal Aayush, Shahi Pradyot, Kumar Somit, Gandhi Ajay, Shyoran Yogendra

机构信息

Urology, Sarder Patel Medical College, Bikaner, IND.

Urology, Sawai Man Singh (SMS) Medical College, Jaipur, IND.

出版信息

Cureus. 2023 Aug 24;15(8):e44021. doi: 10.7759/cureus.44021. eCollection 2023 Aug.

Abstract

Background Hypospadias is a common congenital anomaly that needs repair at an early age (six months to one year). Ironically, many cases in India present late due to a lack of healthcare facilities, poverty, and illiteracy. Adult patients are different from children as they are aware of their genitalia. They are concerned with the aesthetics and, predominantly, the potency. In this study, we present the perspectives and outcomes of 111 adult cases of hypospadias. Methodology In this retrospective study conducted between January 2010 and December 2020, 111 patients aged more than 14 years who were diagnosed with hypospadias of any level with or without mild-to-moderate chordee were included. Hypospadias repair using a tubularized incised plate (TIP) urethroplasty technique was performed, and patients after surgery were followed up at three months, six months, and 12 months for any complications with physical examination, uroflowmetry, and patient-related outcomes (PROs). Results Age varied from 14 years to 32 years (mean = 19.88 years, SD = 5.93). The most frequent meatus positions after chordee adjustment were distal (n = 64, 57.65%), middle (n = 25, 22.52%), and proximal (n = 22, 19.82%). Among these, four patients had penoscrotal transposition. Chordee was present in 65.7% (n = 73) of the cases. (<30° in 38.7%, n = 43; 30°-60° in 23.4%, n = 26, and >60° in 3.6%, n = 4). Chordee was corrected using many techniques, including ventral corporotomies. Urethroplasty was done using TIP and spongioplasty in 89% (n = 99), and one patient underwent inner preputial onlay flap urethroplasty. Snodgraft was used to augment the urethral plate in 10 cases. The success rate of one-stage surgery was 74.77% in our series, which significantly correlated with PROs. Uroflow varied from 12 mL/second to 18 mL/second, and in the majority of the cases, the flow rate improved over time. The most common complication was urethrocutaneous fistula in 11 (11.8%) patients, followed by glanular dehiscence in nine (8.1%) patients. Conclusions Adult patients undergoing primary hypospadias repair generally show good outcomes. Patients can have an acceptable mild degree of residual chordee and torsion, which correlate well with PROs. In our series, hypospadias fistula was the most common complication of hypospadias surgery, followed by glanular dehiscence.

摘要

背景

尿道下裂是一种常见的先天性畸形,需要在幼年时期(6个月至1岁)进行修复。具有讽刺意味的是,由于缺乏医疗设施、贫困和文盲等原因,印度的许多病例就诊较晚。成年患者与儿童不同,因为他们了解自己的生殖器情况。他们关注美观,主要是关注性功能。在本研究中,我们展示了111例成年尿道下裂病例的观点和治疗结果。

方法

在这项于2010年1月至2020年12月进行的回顾性研究中,纳入了111例年龄超过14岁、被诊断为任何程度尿道下裂且伴有或不伴有轻至中度阴茎下弯的患者。采用管状切开包皮板(TIP)尿道成形术技术进行尿道下裂修复,并在术后3个月、6个月和12个月对患者进行随访,通过体格检查、尿流率测定和患者相关结局(PROs)评估有无并发症。

结果

年龄从14岁至32岁不等(平均 = 19.88岁,标准差 = 5.93)。阴茎下弯矫正后最常见的尿道口位置是远端(n = 64,57.65%)、中间(n = 25,22.52%)和近端(n = 22,19.82%)。其中,4例患者有阴茎阴囊转位。65.7%(n = 73)的病例存在阴茎下弯。(<30°的有38.7%,n = 43;30° - 60°的有23.4%,n = 26,>60°的有3.6%,n = 4)。采用多种技术矫正阴茎下弯,包括腹侧白膜切开术。89%(n = 99)的患者采用TIP和海绵体成形术进行尿道成形术,1例患者接受了内包皮嵌合皮瓣尿道成形术。10例患者使用Snodgraft增大尿道板。在我们的系列研究中,一期手术的成功率为74.77%,这与PROs显著相关。尿流率从12毫升/秒至18毫升/秒不等,在大多数病例中,流速随时间有所改善。最常见的并发症是11例(11.8%)患者出现尿道皮肤瘘,其次是9例(8.1%)患者出现龟头裂开。

结论

接受原发性尿道下裂修复的成年患者总体预后良好。患者可能存在可接受的轻度残余阴茎下弯和扭转,这与PROs密切相关。在我们的系列研究中,尿道下裂瘘是尿道下裂手术最常见的并发症,其次是龟头裂开。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a07/10517426/541d648d3015/cureus-0015-00000044021-i01.jpg

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