Smith L T, Holbrook K A
Pediatr Dermatol. 1986 Sep;3(4):271-80. doi: 10.1111/j.1525-1470.1986.tb00525.x.
The process of human dermal development has been examined from the stage of the embryonic mesenchymal dermis (5-8 weeks of gestation) through the formation of the fibrous dermal connective (end of the first trimester), and during the growth of the fetal dermis (second and third trimesters) until birth. The elaboration of dermal organization and the overall increase in dermal thickness, largely consequences of extracellular, fibrous matrix accumulation, parallel the development and growth of the fetus as a whole. Although the mechanisms that determine the formation of the connective tissue architecture are not fully understood, the structural, histochemical, and biochemical changes that occur throughout development suggest processes that may be important in human dermal embryogenesis.
人类皮肤发育过程已从胚胎间充质真皮阶段（妊娠5 - 8周）开始研究，历经纤维性皮肤结缔组织形成（孕早期末），以及胎儿真皮生长阶段（孕中期和孕晚期）直至出生。皮肤组织的精细化以及皮肤厚度的整体增加，在很大程度上是细胞外纤维基质积累的结果，与胎儿整体的发育和生长同步。尽管决定结缔组织结构形成的机制尚未完全明确，但整个发育过程中发生的结构、组织化学和生化变化表明，这些过程可能在人类皮肤胚胎发生中具有重要意义。
