肠病性肢端皮炎毛发的偏振光显微镜检查

Polarization microscopy of hair in acrodermatitis enteropathica.

作者信息

Traupe H, Happle R, Gröbe H, Bertram H P

出版信息

Pediatr Dermatol. 1986 Sep;3(4):300-3. doi: 10.1111/j.1525-1470.1986.tb00529.x.

DOI:10.1111/j.1525-1470.1986.tb00529.x

Abstract

We studied the hair of a 10-month-old girl who was suffering from acrodermatitis enteropathica, using light and polarizing microscopy before and after institution of zinc therapy. The hair was very thin and brittle. On light microscopy the shafts showed uneven diameter and some displayed atypical trichorrhexis nodosa with stretched fractures. Ten percent of the hair fibers exhibited nodal swellings of the pseudomonilethrix type. Polarization microscopy disclosed in 70% of all hair shafts an irregular pattern of alternating dark and bright bands. This anomaly was still present in 10% of the hair shafts after one and one-half years of zinc therapy, but could no longer be detected after two years of zinc supplementation. Repeated determinations of hair probes before and after treatment gave a low cystine content, however, being still in the normal range. We assume that the observed changes and the low hair cystine content can be attributed to the underlying zinc deficiency.

摘要

我们对一名患有肠病性肢端皮炎的10个月大女孩的头发进行了研究，在进行锌治疗前后分别使用光学显微镜和偏光显微镜观察。头发非常稀疏且脆弱。在光学显微镜下，发干直径不均一，有些呈现出非典型结节性脆发症伴有拉伸断裂。10%的毛发纤维表现出假单根毛发结节性肿胀。偏光显微镜显示，70%的发干呈现出明暗交替的不规则条纹。在锌治疗一年半后，10%的发干中仍存在这种异常，但在补锌两年后则无法再检测到。治疗前后对毛发样本的反复测定显示胱氨酸含量较低，不过仍在正常范围内。我们认为观察到的这些变化以及毛发胱氨酸含量低可归因于潜在的锌缺乏。