北印度孕妇群体血浆脂肪酸的参考范围

Reference Range of Plasma Fatty Acids in North Indian Pregnant Population.

作者信息

Thakur Shubham, Kaur Amrit Pal, Singh Kanwardeep, Kaur Rajpinder, Kaur Manpreet, Jain Subheet Kumar

机构信息

Department of Pharmaceutical Sciences, Guru Nanak Dev University, 143005 Amritsar, India.

Department of Obstetrics & Gynaecology, Government Medical College, 143001 Amritsar, India.

出版信息

Indian J Clin Biochem. 2023 Oct;38(4):519-527. doi: 10.1007/s12291-022-01071-7. Epub 2022 Aug 17.

DOI:10.1007/s12291-022-01071-7

PMID:37746532

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10516802/

Abstract

Reference values for Fatty Acids (FAs) are not well defined in the Indian population. Therefore, it is critical to establish FAs reference range for the healthy non-pregnant and pregnant Indian population. The present multi-centric, and cross-sectional study determines the 95% reference interval for FAs in an apparently pregnant Indian population and compare it to the healthy non-pregnant women. Physicians identified 164 reference individuals as healthy (56 non-pregnant and 108 pregnant) at various government and private hospitals of northern India. The 95th and 97.5th percentile reference limits were used to estimate the 95 percentile of the reference distribution. The reference ranges observed for Alpha-linolenic acid (0.29-0.42%; 0.36-0.58%), Docosahexaenoic-acid (3.38-4.23%; 3.8-4.55%), Eicosapentaenoic-acid (1.24-1.76%; 1.09-1.62%), Docosapentaenoic-acid-3 (0.61-0.69%; 0.65-0.76%), Linoleic-acid (18.44-20.75%; 19.51-21.88%), gamma-linolenic-acid (0.24-0.35%; 0.32-0.42%), Eicosatrienoic-acid (0.26-0.32%; 0.34-0.39%), Arachidonic-acid (9.29-11.02%; 10.02-11.56%), Docosatetraenoic-acid (0.62-0.89%; 0.79-1.09%), Docosapentaenoic-acid-6 (0.23-0.31%; 0.33-0.41%), Eicosatrienoic-acid (1.17-1.41%; 1.43-1.74%), Eicosenoic-acid (0.28-0.38%; 0.37-0.49%), Nervonic-acid (1.39-1.69%; 1.41-1.74%), Palmitoleic-acid (1.17-1.58%; 2-2.66%), Oleic-acid (19.8-22.26%; 19.68-22.94%), Myristic-acid (1.16-1.68%; 0.82-1.3%), Palmitic-acid (20.05-21.8%; 20.7-22.43%), Stearic-acid (11.34-12.56%; 10.29-11.02%), Arachidic-acid (0.17-0.2%; 0.18-0.23%), Lignoceric-acid (0.81-1.08%; 0.77-1.08%), -palmitoleic-acid (0.22-0.29%; 0.26-0.37%), -oleic-acid (0.55-0.72%; 0.68-0.84%), -linoleic-acid (0.38-0.54%; 0.42-0.59%) respectively for non-pregnant and pregnant women. Furthermore, total FAs were significantly (p ≤ 0:05) higher in women aged 31-45 years than in women aged 16-30 years. whereas, there was no significant change in total FAs profile based on omega-supplementation, diet category, preterm-birth history, and gestation period. Thus, the current study provides information about an individual who is deficient in FAs and the dose required to increase FA concentrations in the body.

摘要

在印度人群中，脂肪酸（FAs）的参考值尚未明确界定。因此，为健康的未怀孕和怀孕印度人群建立脂肪酸参考范围至关重要。本多中心横断面研究确定了明显怀孕的印度人群中脂肪酸的95%参考区间，并将其与健康未怀孕女性进行比较。医生在印度北部的多家政府和私立医院确定了164名健康参考个体（56名未怀孕和108名怀孕）。使用第95和第97.5百分位数参考限值来估计参考分布的第95百分位数。未怀孕和怀孕女性的α-亚麻酸（0.29 - 0.42%；0.36 - 0.58%）、二十二碳六烯酸（3.38 - 4.23%；3.8 - 4.55%）、二十碳五烯酸（1.24 - 1.76%；1.09 - 1.62%）、二十二碳五烯酸-3（0.61 - 0.69%；0.65 - 0.76%）、亚油酸（18.44 - 20.75%；19.51 - 21.88%）、γ-亚麻酸（0.24 - 0.35%；0.32 - 0.42%）、二十碳三烯酸（0.26 - 0.32%；0.34 - 0.39%）、花生四烯酸（9.29 - 11.02%；10.02 - 11.56%）、二十二碳四烯酸（0.62 - 0.89%；0.79 - 1.09%）、二十二碳五烯酸-6（0.23 - 0.31%；0.33 - 0.41%）、二十碳三烯酸（1.17 - 1.41%；1.43 - 1.74%）、二十碳烯酸（0.28 - 0.38%；0.37 - 0.49%）、神经酸（1.39 - 1.69%；1.41 - 1.74%）、棕榈油酸（1.17 - 1.58%；2 - 2.66%）、油酸（19.8 - 22.26%；19.68 - 22.94%）、肉豆蔻酸（1.16 - 1.68%；0.82 - 1.3%）、棕榈酸（20.05 - 21.8%；20.7 - 22.43%）、硬脂酸（11.34 - 12.56%；10.29 - 11.02%）、花生酸（0.17 - 0.2%；0.18 - 0.23%）、木蜡酸（0.81 - 1.08%；0.77 - 1.08%）、反式棕榈油酸（0.22 - 0.29%；0.26 - 0.37%）、反式油酸（0.55 - 0.72%；0.68 - 0.84%）、反式亚油酸（0.38 - 0.54%；0.42 - 0.59%）的参考范围分别如下。此外，31 - 45岁女性的总脂肪酸含量显著高于16 - 30岁女性（p≤0.05）。然而，基于ω-补充剂、饮食类别、早产史和妊娠期，总脂肪酸谱没有显著变化。因此，本研究提供了关于脂肪酸缺乏个体以及增加体内脂肪酸浓度所需剂量的信息。