抗氧化酶与冠状动脉粥样硬化男性血液中脂肪酸浓度的关联

Associations of Antioxidant Enzymes with the Concentration of Fatty Acids in the Blood of Men with Coronary Artery Atherosclerosis.

作者信息

Shramko Viktoriya S, Striukova Eugeniia V, Polonskaya Yana V, Stakhneva Ekaterina M, Volkova Marina V, Kurguzov Alexey V, Kashtanova Elena V, Ragino Yuliya I

机构信息

Research Institute of Internal and Preventive Medicine, Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.

Federal State Budgetary Institution "National Medical Research Center Named Academician E.N. Meshalkin", Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia.

出版信息

J Pers Med. 2021 Dec 2;11(12):1281. doi: 10.3390/jpm11121281.

DOI:10.3390/jpm11121281

PMID:34945751

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8704768/

Abstract

OBJECTIVE

To identify associations of fatty acids (FAs) with the antioxidant enzymes in the blood of men with coronary atherosclerosis and ischemic heart disease (IHD).

METHODS

The study included 80 patients: control group-20 men without IHD, the core group-60 men with IHD. The core group was divided into subgroups: subgroup A-with the presence of vulnerable atherosclerotic plaques, subgroup B-with the absence of vulnerable atherosclerotic plaques. We analyzed the levels of FAs, free radicals, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the blood.

RESULTS

Patients with IHD, compared with the control group: (1) had higher levels of SOD, CAT, myristic, palmitic, palmitoleic, and octadecenoic FAs; (2) had lower levels of GPx, α-linolenic, docosapentaenoic, docosahexaenoic, and arachidonic FAs. In subgroup A there were found: (1) negative associations of SOD-with linoleic, eicosatrienoic, arachidonic, eicosapentaenoic, docosapentaenoic and docosahexaenoic FAs, positive associations-with palmitic acid; (2) positive correlations of CAT level with palmitoleic and stearic acids; (3) negative associations between of GPx and palmitic, palmitoleic, stearic and octadecenoic FAs.

CONCLUSIONS

Changes in the levels of antioxidant enzymes, and a disbalance of the FAs profile, probably indicate active oxidative processes in the body and may indicate the presence of atherosclerotic changes in the vessels.

摘要

目的

确定脂肪酸（FAs）与患有冠状动脉粥样硬化和缺血性心脏病（IHD）男性血液中抗氧化酶之间的关联。

方法

该研究纳入80例患者：对照组20名无IHD的男性，核心组60名患有IHD的男性。核心组又分为亚组：亚组A——存在易损动脉粥样硬化斑块，亚组B——不存在易损动脉粥样硬化斑块。我们分析了血液中FAs、自由基、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的水平。

结果

与对照组相比，IHD患者：（1）SOD、CAT、肉豆蔻酸、棕榈酸、棕榈油酸和十八碳烯酸水平较高；（2）GPx、α-亚麻酸、二十二碳五烯酸、二十二碳六烯酸和花生四烯酸水平较低。在亚组A中发现：（1）SOD与亚油酸、二十碳三烯酸、花生四烯酸、二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸呈负相关，与棕榈酸呈正相关；（2）CAT水平与棕榈油酸和硬脂酸呈正相关；（3）GPx与棕榈酸、棕榈油酸、硬脂酸和十八碳烯酸呈负相关。