Kusunoki Masataka, Tsutsumi Kazuhiko, Nakayama Meiho, Kurokawa Tsuyoshi, Nakamura Takao, Ogawa Hitoshi, Fukuzawa Yoshitaka, Morishita Munehiko, Koide Tatsuro, Miyata Tetsuro
Aichi Medical University, Medical Clinic, Aichi, Japan.
J Med Invest. 2007 Aug;54(3-4):243-7. doi: 10.2152/jmi.54.243.
Consumption of polyunsaturated fatty acids (PUFA) improves the lipid metabolism of diabetics, leading to prevents of arteriosclerosis. Exact relationship between saturated fatty acids (SFA) or PUFA and the insulin resistance of diabetics are unknown.
We investigated the relationship between the serum concentrations of saturated and unsaturated fatty acids and the homeostasis model insulin resistance index (HOMA-R) in Japanese patients with type 2 diabetes mellitus.
The SFA, i.e., lauric acid, myristic acid, palmitic acid, and stearic acid; the monounsaturated fatty acids (MUFA), i.e., palmitoleic acid, oleic acid, and erucic acid; and the PUFA, i.e., eicosadienoic acid, dihomo-gamma-linolenic acid, docosatetraenoic acid, and docosapentaenoic acid were positively correlated with HOMA-R. However, no correlations were found between HOMA-R and SFA, i.e., arachidic acid, behenic acid, and lignoceric acid; the MUFA, i.e., eicosenoic acid and nervonic acid; and the PUFA, i.e., linoleic acid, gamma-linolenic acid, linolenic acid, 5-8-11 eicosatrienoic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid.
Some PUFA as well as SFA were positively correlated with HOMA-R. These results indicate that the intake of diet fatty acid must be well balanced in diabetic patients and it is not always true to refrain from taking SFA and increase the unsaturated fatty acids in their diets.
多不饱和脂肪酸（PUFA）的摄入可改善糖尿病患者的脂质代谢，从而预防动脉硬化。饱和脂肪酸（SFA）或PUFA与糖尿病患者胰岛素抵抗的确切关系尚不清楚。
我们研究了日本2型糖尿病患者血清中饱和脂肪酸和不饱和脂肪酸浓度与稳态模型胰岛素抵抗指数（HOMA-R）之间的关系。
月桂酸、肉豆蔻酸、棕榈酸和硬脂酸等饱和脂肪酸；棕榈油酸、油酸和芥酸等单不饱和脂肪酸（MUFA）；以及二十碳二烯酸、二高-γ-亚麻酸、二十二碳四烯酸和二十二碳五烯酸等多不饱和脂肪酸与HOMA-R呈正相关。然而，花生酸、山嵛酸和木蜡酸等饱和脂肪酸；二十碳烯酸和神经酸等单不饱和脂肪酸；以及亚油酸、γ-亚麻酸、亚麻酸、5,8,11-二十碳三烯酸、花生四烯酸、二十碳五烯酸和二十二碳六烯酸等多不饱和脂肪酸与HOMA-R之间未发现相关性。
一些多不饱和脂肪酸以及饱和脂肪酸与HOMA-R呈正相关。这些结果表明，糖尿病患者饮食中脂肪酸的摄入必须保持良好平衡，并非总是要避免摄入饱和脂肪酸并增加饮食中的不饱和脂肪酸。
