miR-149 rs2292832 C>T 多态性与胃癌风险关联的研究进展：一项胃肠道癌症的荟萃分析研究。

Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers.

机构信息

Department of Gastroenterology, The People's Hospital of Yichun City, Yichun, Jiangxi, China.

Department of Urology, The People's Hospital of Yichun City, Yichun, Jiangxi, China.

出版信息

Medicine (Baltimore). 2023 Sep 22;102(38):e35202. doi: 10.1097/MD.0000000000035202.

DOI:10.1097/MD.0000000000035202

PMID:37747007

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10519566/

Abstract

OBJECTIVE

Single nucleotide polymorphisms in microRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of microRNAs. Several studies investigated the role of the miR-149 rs2292832 C>T polymorphism on the risk of gastric cancer (GC), but got conflicting results.

METHODS

We performed a comprehensive and systematic search through the PubMed MEDLINE, Google Scholar, Science Direct, Scopus, CNKI, and Web of science, 8 studies were included in the meta-analysis to determine whether miR-149 rs2292832 C>T polymorphism contributed to the risk of GC.

RESULTS

Pooled data indicated that miR-149 rs2292832 C>T polymorphism was not associated with GC risk. In the stratified analysis by ethnicity, miR-149 rs2292832 C>T polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.27, 95% CI = 1.04-1.55, Pheterogeneity = 0.18, P = .02), recessive model (OR = 1.44, 95% CI = 1.04-2.01, Pheterogeneity = 0.19, P = .03) among Caucasians; but decreased GC risk under the allele comparison model (OR = 0.89, 95% CI = 0.81-0.98, Pheterogeneity = 0.22, P = .02) and dominant model (OR = 0.82, 95% CI = 0.72-0.93, Pheterogeneity = 0.15, P = .01) among Asian.

CONCLUSION

Our meta-analysis suggests a positive correlation between miR-149 rs2292832 C>T polymorphism and GC development among Caucasians, but negative correlation among Asian population.

摘要

目的

单核苷酸多态性（SNP）被认为可以通过改变 microRNA 的表达和生物学功能，从而影响癌症的发生和发展。有几项研究探讨了 miR-149 rs2292832 C>T 多态性与胃癌（GC）风险的关系，但结果存在矛盾。

方法

我们通过 PubMed MEDLINE、Google Scholar、Science Direct、Scopus、CNKI 和 Web of science 进行了全面系统的检索，共纳入 8 项研究进行荟萃分析，以确定 miR-149 rs2292832 C>T 多态性是否与 GC 风险相关。

结果

汇总数据表明，miR-149 rs2292832 C>T 多态性与 GC 风险无关。按种族进行分层分析时，在等位基因比较模型下（比值比[OR] = 1.27，95%可信区间[CI] = 1.04-1.55，P 异质性= 0.18，P= 0.02），miR-149 rs2292832 C>T 多态性显著增加了高加索人群的 GC 风险；但在隐性模型下（OR = 1.44，95% CI = 1.04-2.01，P 异质性= 0.19，P= 0.03），miR-149 rs2292832 C>T 多态性降低了 GC 风险；在亚洲人群中，miR-149 rs2292832 C>T 多态性在等位基因比较模型下（OR = 0.89，95% CI = 0.81-0.98，P 异质性= 0.22，P= 0.02）和显性模型下（OR = 0.82，95% CI = 0.72-0.93，P 异质性= 0.15，P= 0.01）降低了 GC 风险。