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Making Mountains out of Mole Hills: The Role of CD36 in Oxidized Phospholipid-driven Lung Injury.小题大做：CD36在氧化磷脂驱动的肺损伤中的作用
Am J Respir Cell Mol Biol. 2024 Jan;70(1):3-4. doi: 10.1165/rcmb.2023-0312ED.
2
Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36.鉴定出一类新型氧化磷脂，其作为巨噬细胞清道夫受体CD36的配体。
J Biol Chem. 2002 Oct 11;277(41):38503-16. doi: 10.1074/jbc.M203318200. Epub 2002 Jul 8.
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The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein.氧化型低密度脂蛋白与小鼠CD36的结合部分是由与脂蛋白的脂质和蛋白质部分相关的氧化磷脂介导的。
J Biol Chem. 2000 Mar 31;275(13):9163-9. doi: 10.1074/jbc.275.13.9163.
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Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI.B 类清道夫受体 CD36 和 SR-BI 识别氧化型低密度脂蛋白中氧化磷脂的结构基础。
J Biol Chem. 2010 Feb 12;285(7):4447-54. doi: 10.1074/jbc.M109.082800. Epub 2009 Dec 8.
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A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.一类新的致动脉粥样硬化氧化磷脂通过清道夫受体CD36促进巨噬细胞泡沫细胞形成，并在动脉粥样硬化病变中富集。
J Biol Chem. 2002 Oct 11;277(41):38517-23. doi: 10.1074/jbc.M205924200. Epub 2002 Jul 26.
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Aging-Related Accumulation of Truncated Oxidized Phospholipids Augments Infectious Lung Injury and Endothelial Dysfunction via Cluster of Differentiation 36-Dependent Mechanism.衰老相关截断氧化磷脂的积累通过分化群 36 依赖性机制增强感染性肺损伤和血管内皮功能障碍。
Cells. 2023 Jul 26;12(15):1937. doi: 10.3390/cells12151937.
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Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters.特定的氧化磷脂抑制清道夫受体B1介导的胆固醇酯选择性摄取。
J Biol Chem. 2008 Apr 18;283(16):10408-14. doi: 10.1074/jbc.M710474200. Epub 2008 Feb 19.
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Phospholipid hydroxyalkenals, a subset of recently discovered endogenous CD36 ligands, spontaneously generate novel furan-containing phospholipids lacking CD36 binding activity in vivo.磷脂羟基烯醛是最近发现的内源性CD36配体的一个子集，在体内可自发产生缺乏CD36结合活性的新型含呋喃磷脂。
J Biol Chem. 2006 Oct 20;281(42):31298-308. doi: 10.1074/jbc.M604039200. Epub 2006 Aug 14.
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Mapping and characterization of the binding site for specific oxidized phospholipids and oxidized low density lipoprotein of scavenger receptor CD36.清道夫受体CD36特异性氧化磷脂和氧化低密度脂蛋白结合位点的定位与表征
J Biol Chem. 2008 Mar 28;283(13):8765-71. doi: 10.1074/jbc.M709195200. Epub 2008 Feb 1.
10
Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice.载脂蛋白 A-I 在 CD36 基因敲除小鼠肝脏中的分泌增强及其在血循环中的胆固醇和磷脂外排。
PLoS One. 2010 Mar 26;5(3):e9906. doi: 10.1371/journal.pone.0009906.

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1
Oxidation of low-density lipoprotein by hemoglobin causes pulmonary microvascular endothelial barrier dysfunction through lectin-like oxidized LDL receptor 1.血红蛋白介导的低密度脂蛋白氧化通过凝集素样氧化型低密度脂蛋白受体1导致肺微血管内皮屏障功能障碍。
Am J Physiol Lung Cell Mol Physiol. 2025 May 1;328(5):L748-L755. doi: 10.1152/ajplung.00026.2025. Epub 2025 Apr 18.

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1
Amphipathic Helical Peptide L37pA Protects against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor.两亲性螺旋肽 L37pA 通过与 CD36 受体拮抗作用，预防截短氧化磷脂引起的肺血管内皮功能障碍。
Am J Respir Cell Mol Biol. 2024 Jan;70(1):11-25. doi: 10.1165/rcmb.2023-0127OC.
2
Scavenger receptor BI attenuates oxidized phospholipid-induced pulmonary inflammation.清道夫受体 BI 可减轻氧化磷脂诱导的肺部炎症。
Toxicol Appl Pharmacol. 2023 Mar 1;462:116381. doi: 10.1016/j.taap.2023.116381. Epub 2023 Jan 19.
3
Upregulation of cluster of differentiation 36 mRNA expression in peripheral blood mononuclear cells correlates with frailty severity in older adults.外周血单个核细胞中分化群 36mRNA 表达的上调与老年人虚弱严重程度相关。
J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1948-1955. doi: 10.1002/jcsm.13003. Epub 2022 Apr 17.
4
Oxidized phospholipids and lipoprotein(a): An update.氧化磷脂与脂蛋白(a)：最新进展
Eur J Clin Invest. 2022 Apr;52(4):e13710. doi: 10.1111/eci.13710. Epub 2021 Nov 27.
5
Role of truncated oxidized phospholipids in acute endothelial barrier dysfunction caused by particulate matter.截断氧化磷脂在颗粒物引起的急性内皮屏障功能障碍中的作用。
PLoS One. 2018 Nov 12;13(11):e0206251. doi: 10.1371/journal.pone.0206251. eCollection 2018.
6
Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue.瘦体和肥胖脂肪组织中鉴定出的氧化磷脂控制着巨噬细胞表型和生物能量。
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6254-E6263. doi: 10.1073/pnas.1800544115. Epub 2018 Jun 11.
7
Synthetic Amphipathic Helical Peptides Targeting CD36 Attenuate Lipopolysaccharide-Induced Inflammation and Acute Lung Injury.靶向CD36的合成两亲性螺旋肽减轻脂多糖诱导的炎症和急性肺损伤。
J Immunol. 2016 Jul 15;197(2):611-9. doi: 10.4049/jimmunol.1401028. Epub 2016 Jun 17.
8
Identification of oxidized phospholipids in bronchoalveolar lavage exposed to low ozone levels using multivariate analysis.使用多变量分析鉴定暴露于低臭氧水平的支气管肺泡灌洗中的氧化磷脂。
Anal Biochem. 2015 Apr 1;474:50-8. doi: 10.1016/j.ab.2014.12.018. Epub 2015 Jan 7.
9
CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior.CD36，一种参与免疫、代谢、血管生成和行为的清道夫受体。
Sci Signal. 2009 May 26;2(72):re3. doi: 10.1126/scisignal.272re3.
10
The role of oxidized phospholipids in atherosclerosis.氧化磷脂在动脉粥样硬化中的作用。
J Lipid Res. 2009 Apr;50 Suppl(Suppl):S207-12. doi: 10.1194/jlr.R800074-JLR200. Epub 2008 Dec 4.

Making Mountains out of Mole Hills: The Role of CD36 in Oxidized Phospholipid-driven Lung Injury.

作者信息

Yaeger Michael J, Shaikh Saame Raza, Gowdy Kymberly M

机构信息

Wexner Medical Center The Ohio State University Columbus, Ohio.

Gillings School of Global Public Health.

出版信息

Am J Respir Cell Mol Biol. 2024 Jan;70(1):3-4. doi: 10.1165/rcmb.2023-0312ED.

DOI:10.1165/rcmb.2023-0312ED
PMID:37747355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10768831/
Abstract
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