University Medical Centre Ljubljana, Department of Abdominal Surgery, Zaloska 7, SI-1000 Ljubljana, Slovenia; University of Ljubljana, Medical Faculty, Vrazov trg 2, 1000 Ljubljana, Slovenia.
Institute of Oncology Ljubljana, Department of Experimental Oncology, Zaloska 2, SI-1000 Ljubljana, Slovenia; University of Primorska, Faculty of Health Sciences, Polje 42, SI-6310 Izola, Slovenia.
Bioelectrochemistry. 2024 Feb;155:108576. doi: 10.1016/j.bioelechem.2023.108576. Epub 2023 Sep 22.
Despite extensive research in recent decades, pancreatic cancer continues to be among the most lethal forms of cancer, with no substantial increase in survival rates. Local recurrences account for approximately 30 per cent of all disease recurrences. With the intent to improve survival, we designed a novel, hybrid treatment strategy consisting of surgical resection and additional intraoperative electrochemotherapy of the posterior resection surface. We present the study protocols and preliminary findings of a prospective pilot study investigating this treatment approach.
Consenting patients with resectable pancreatic head ductal adenocarcinoma who met the inclusion criteria were enrolled in the study. After surgical resection, electrochemotherapy with bleomycin was performed using plate electrodes to cover the area between anatomical landmarks.
Electrochemotherapy of the posterior resection surface was feasible in all 7 patients. We observed pancreatic fistula grade B in only one patient; all other noted complications were Clavien-Dindo grade 2 or less. The hospital mortality was 0%.
Our preliminary results suggest that a hybrid approach combining surgery with intraoperative electrochemotherapy is safe and feasible.
尽管近几十年来进行了广泛的研究，但胰腺癌仍然是最致命的癌症之一，生存率没有实质性提高。局部复发约占所有疾病复发的 30%。为了提高生存率，我们设计了一种新的混合治疗策略，包括手术切除和对后切除面进行额外的术中电化学治疗。我们提出了一项前瞻性试点研究的研究方案和初步结果，该研究调查了这种治疗方法。
符合纳入标准的可切除胰腺头部导管腺癌患者同意参加研究。手术切除后，使用极板电极进行博来霉素电化学治疗，以覆盖解剖标志之间的区域。
7 名患者的后切除面电化学治疗均可行。我们仅在 1 名患者中观察到 B 级胰瘘；其他所有观察到的并发症均为 Clavien-Dindo 分级 2 级或更低。住院死亡率为 0%。
我们的初步结果表明，结合手术和术中电化学治疗的混合方法是安全可行的。
