Opportunistic Computed Tomography Screening for Osteoporosis and Fracture.

Osteoporosis is underdiagnosed and undertreated, leading to loss of treatment for the patient and high costs for the health care system. Routine thoracic and/or abdominal computed tomography (CT) performed for other indications can screen opportunistically for osteoporosis with no extra cost, time, or irradiation. Various methods can quantify fracture risk on opportunistic clinical CT: vertebral Hounsfield unit bone mineral density (BMD), usually of L1; BMD measurement with asynchronous or internal calibration; quantitative CT; bone texture assessment; and finite element analysis. Screening for osteoporosis and vertebral fractures on opportunistic CT is a promising approach, providing automated fracture risk scores by means of artificial intelligence, thus enabling earlier management.