全球儿童和青少年隐匿性乙型肝炎病毒感染的流行率：系统评价和荟萃分析。
Global prevalence of occult HBV infection in children and adolescents: A systematic review and meta-analysis.
机构信息
Department of Infectious Diseases, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing, China; The First batch of key Disciplines On Public Health in Chongqing, Health Commission of Chongqing, Chongqing, China.
Affiliated Hospital of Chengdu University, Chengdu, China.
出版信息
Ann Hepatol. 2024 Jan-Feb;29(1):101158. doi: 10.1016/j.aohep.2023.101158. Epub 2023 Sep 23.
INTRODUCTION AND OBJECTIVES
Occult HBV infection (OBI) is a specific form of hepatitis B virus (HBV) infection and has the possibility of developing into hepatocellular carcinoma (HCC) in adults. This study aimed to estimate the global prevalence of occult HBV infection in children and adolescents.
MATERIALS AND METHODS
We systematically searched PubMed, Embase, Web of Science, and Cochrane databases for relevant studies on the prevalence of OBI in children and adolescents. Meta-analysis was performed using STATA 16 software.
RESULTS
Fifty studies were included. The overall prevalence of OBI in children and adolescents was 7.5% (95% CI: 0.050-0.103). In different risk populations, OBI prevalence was remarkably high in the HIV-infected population (24.2%, 95% CI: 0.000-0.788). The OBI prevalence was 0.8% (95% CI:0.000-0.029) in the healthy population, 3.8% (95% CI:0.012-0.074) in the general population, and 6.4% (95% CI: 0.021-0.124) in children born to HBsAg-positive mothers. Based on different serological profiles, the prevalence of OBI in HBsAg-negative and anti-HBc-positive patients was 6.6% (95% CI: 0.016-0.136), 3.0% (95% CI: 0.009-0.059) in HBsAg-negative and anti-HBc-negative patients, 4.6% (95% CI: 0.015-0.088) in HBsAg-negative and anti-HBs-positive patients, and 3.7% (95% CI: 0.001-0.102) in HBsAg-negative and anti-HBs-negative patients.
CONCLUSIONS
Despite HBV vaccination and hepatitis B immunoglobulin (HBIG), OBI is common in children and adolescents in high-risk groups.
简介与目的
隐匿性乙型肝炎病毒（HBV）感染是一种特殊形式的乙型肝炎病毒（HBV）感染，有可能在成人中发展为肝细胞癌（HCC）。本研究旨在估计全球儿童和青少年隐匿性 HBV 感染的流行率。
材料与方法
我们系统地检索了 PubMed、Embase、Web of Science 和 Cochrane 数据库中有关儿童和青少年隐匿性 HBV 感染流行率的研究。使用 STATA 16 软件进行荟萃分析。
结果
共纳入 50 项研究。儿童和青少年隐匿性 HBV 感染的总体流行率为 7.5%（95%CI：0.050-0.103）。在不同的风险人群中，HIV 感染者中的隐匿性 HBV 感染率显著较高（24.2%，95%CI：0.000-0.788）。健康人群中的隐匿性 HBV 感染率为 0.8%（95%CI：0.000-0.029），一般人群为 3.8%（95%CI：0.012-0.074），HBsAg 阳性母亲所生儿童为 6.4%（95%CI：0.021-0.124）。基于不同的血清学特征，HBsAg 阴性和抗-HBc 阳性患者中的隐匿性 HBV 感染率为 6.6%（95%CI：0.016-0.136），HBsAg 阴性和抗-HBc 阴性患者为 3.0%（95%CI：0.009-0.059），HBsAg 阴性和抗-HBs 阳性患者为 4.6%（95%CI：0.015-0.088），HBsAg 阴性和抗-HBs 阴性患者为 3.7%（95%CI：0.001-0.102）。
结论
尽管进行了乙型肝炎病毒疫苗接种和乙型肝炎免疫球蛋白（HBIG）接种，高危人群中的儿童和青少年仍普遍存在隐匿性 HBV 感染。
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