Rüesch Annia, Ip Cheng-Teng, Bankwitz Anna, Villar de Araujo Tania, Hörmann Christoph, Adank Atalìa, Schoretsanitis Georgios, Kleim Birgit, Olbrich Sebastian
University of Zurich, Psychiatric University Hospital Zurich, Department of Psychiatry, Psychotherapy and Psychosomatics, Zurich, Switzerland.
Center for Cognitive and Brain Sciences, University of Macau, Taipa, Macau SAR, China.
Clin Neurophysiol. 2023 Dec;156:272-280. doi: 10.1016/j.clinph.2023.08.018. Epub 2023 Sep 6.
Decades of research have not yet produced statistically reliable predictors of preparatory behavior eventually leading to suicide attempts or deaths by suicide. As the nature of suicidal behavior is complex, it is best investigated in a transdiagnostic approach, while assessing objective markers, as proposed by the Research Domain Criteria (Cuthbert, 2013).
A 15-min resting-state EEG was recorded in 45 healthy controls, and 49 transdiagnostic in-patients with a recent (<6 months) suicide attempt. Brain arousal regulation in eyes-closed condition was assessed with the Vigilance Algorithm Leipzig (VIGALL) (Sander et al., 2015).
A significant incline of median vigilance and vigilance slope was observed in patients within the first 3-min of the EEG recording. Additionally, a significant positive correlation of self-reported suicidal ideation with the vigilance slope over 15-min recording time, as well as a significant negative correlation with EEG vigilance stage A1 during the first 3-min was found.
Transdiagnostic patients with a recent suicide attempt show a distinct vigilance regulation pattern. Further studies including a control group consisting of patients without life-time suicide attempts are needed to increase the clinical utility of the findings.
These findings might serve as potential objective markers of suicidal behavior.
数十年的研究尚未得出关于最终导致自杀未遂或自杀死亡的预备行为的统计学可靠预测指标。由于自杀行为的性质复杂，最好采用跨诊断方法进行研究，同时按照研究领域标准（卡斯伯特，2013年）评估客观指标。
对45名健康对照者和49名近期（<6个月）有自杀未遂经历的跨诊断住院患者进行了15分钟的静息态脑电图记录。采用莱比锡警觉算法（VIGALL）（桑德等人，2015年）评估闭眼状态下的大脑觉醒调节。
在脑电图记录的前3分钟内，患者的中位警觉性和警觉斜率出现显著上升。此外，在15分钟的记录时间内，自我报告的自杀意念与警觉斜率呈显著正相关，在前3分钟内与脑电图警觉阶段A1呈显著负相关。
近期有自杀未遂经历的跨诊断患者表现出独特的警觉调节模式。需要进一步开展研究，纳入无终生自杀未遂经历患者组成的对照组，以提高研究结果的临床实用性。
这些发现可能作为自杀行为的潜在客观指标。
