Martins Guilherme M, Simoso Guilherme B, de Castro Pedro P, de Lucca Felipe, Mendes Samuel R, Brocksom Timothy J, de Oliveira Kleber T
Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo 13565-905, Brazil.
Department of Pharmacy, Federal University of Juiz de Fora─Campus Governador Valadares, Governador Valadares, Minas Gerais 35010-177, Brazil.
J Org Chem. 2025 Jul 11;90(27):9532-9540. doi: 10.1021/acs.joc.5c00967. Epub 2025 Jun 29.
The synthesis of isochromene and dihydroisobenzofuran compounds is presented through the electrochemical cyclization of 2-ethynylbenzaldehydes using silver as a sacrificial electrode. The results demonstrate exceptional regiodivergency, without the use of external oxidants or transition metal catalysts, with products reaching up to 97% isolated yield. Density functional theory (DFT) studies, along with control experiments, were conducted to elucidate a plausible reaction mechanism.
通过使用银作为牺牲电极对2-乙炔基苯甲醛进行电化学环化反应，实现了异苯并呋喃和二氢异苯并呋喃化合物的合成。结果表明，该反应具有出色的区域发散性，无需使用外部氧化剂或过渡金属催化剂，产物的分离产率高达97%。进行了密度泛函理论（DFT）研究以及对照实验，以阐明可能的反应机理。
