Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.
Hematology, Blood & Marrow Transplant, and Cellular Therapies Program, University of California San Francisco, San Francisco, CA.
Semin Oncol Nurs. 2023 Dec;39(6):151505. doi: 10.1016/j.soncn.2023.151505. Epub 2023 Sep 24.
Approvals of chimeric antigen receptor T-cell (CAR-T) therapies for relapsed/refractory multiple myeloma (RRMM) represent advancements in treatment options for a hard-to-treat population. Nursing care during CAR-T therapy is crucial for patients, their caregivers, and the broader CAR-T therapy care team. This manuscript provides an overview of the CAR-T therapy administration process and describes practical considerations for nursing professionals working with patients who receive CAR-T therapy.
Current literature describing CAR-T therapies for RRMM and published guidelines on nursing care during CAR-T therapy administration were identified from a PubMed database search. Literature was synthesized with practical considerations from nurses and nurse practitioners with expertise in the administration of CAR-T therapy for MM. A practical overview of the role of nursing professionals throughout all stages of CAR-T therapy administration for RRMM is provided.
Planning, administration, and posttreatment monitoring for CAR-T therapy requires collaboration between nursing professionals and other healthcare providers as patients migrate between community oncology providers and specialized treatment centers. Nurses help with assessment of patient eligibility and patient and caregiver education before CAR-T therapy. They act in diverse roles across various settings involved in CAR-T therapy administration. Finally, nurses contribute to long-term identification and management of CAR-T-associated toxicities.
Nurses are crucial to the CAR-T therapy process and make significant contributions to optimizing patient care and subsequent outcomes.
嵌合抗原受体 T 细胞（CAR-T）疗法获批用于治疗复发性/难治性多发性骨髓瘤（RRMM），为这一难治疗人群提供了更多治疗选择。CAR-T 治疗期间的护理对于患者、其照护者以及更广泛的 CAR-T 治疗护理团队至关重要。本文概述了 CAR-T 治疗的给药流程，并描述了护理专业人员在为接受 CAR-T 治疗的患者提供护理时需要考虑的实际问题。
从 PubMed 数据库检索到描述 RRMM 用 CAR-T 疗法的当前文献和关于 CAR-T 治疗给药期间护理的已发表指南。对来自具有 MM 用 CAR-T 治疗给药专业知识的护士和执业护师的实际考虑进行综合，提供了 RRMM 用 CAR-T 治疗管理所有阶段护理专业人员作用的实用概述。
CAR-T 治疗的规划、给药和治疗后监测需要护理专业人员与其他医疗保健提供者之间的协作，因为患者在社区肿瘤学提供者和专门治疗中心之间转移。护士在 CAR-T 治疗前协助评估患者的资格和患者及照护者教育。他们在 CAR-T 治疗管理所涉及的各种环境中扮演多种角色。最后，护士有助于识别和长期管理与 CAR-T 相关的毒性。
护士是 CAR-T 治疗过程中不可或缺的一部分，对优化患者护理和随后的结果做出了重大贡献。
