Wu F, Deng Z S, Tian H S, Li H Q, Zhou Y M
Guangzhou Institute of Respiratory Health (National Clinical Research Center for Respiratory Diseases, State Key Laboratory for Respiratory Disease, National Center for Respiratory Medicine), The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Laboratory, Guangzhou 510005, China.
Guangzhou Institute of Respiratory Health (National Clinical Research Center for Respiratory Diseases, State Key Laboratory for Respiratory Disease, National Center for Respiratory Medicine), The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2023 Oct 12;46(10):1028-1034. doi: 10.3760/cma.j.cn112147-20230223-00085.
Pre-chronic obstructive pulmonary disease (Pre-COPD) refers to individuals with chronic respiratory symptoms, structural abnormalities, and/or functional abnormalities, in the absence of airflow limitation, who may develop persistent airflow limitation over time. COPD is characterized by high prevalence and great heterogeneity and complexity. Early multidimensional identification and promotion of early prevention, management and treatment of Pre-COPD can help delay or halt the development of COPD, which has significant public health implications. This review aimed to summarize the definition, relevant cohorts, clinical trials, and other research progress in pre-COPD in order to improve the understanding of individuals with pre-COPD and improve early prevention and management of COPD.
慢性阻塞性肺疾病前期（Pre-COPD）指的是那些有慢性呼吸道症状、结构异常和/或功能异常，但不存在气流受限的个体，这些个体随着时间推移可能会出现持续性气流受限。慢性阻塞性肺疾病（COPD）具有高患病率以及极大的异质性和复杂性。对Pre-COPD进行早期多维度识别并推动其早期预防、管理和治疗，有助于延缓或阻止COPD的发展，这具有重大的公共卫生意义。本综述旨在总结Pre-COPD的定义、相关队列、临床试验及其他研究进展，以增进对Pre-COPD个体的认识，并改善COPD的早期预防和管理。
