Banciu T, Kozicek C
Med Interne. 1986 Jul-Sep;24(3):235-8.
The action of an inhibitor of the calcium channels (Verapamil) on stimulated gastric acid secretion was studied in 14 patients with duodenal ulcer. Two histamine stimulations (0.5 mg) of acid gastric secretion were performed at an interval of 48 hrs, the second being preceded by Verapamil administration in doses of 80 or 120 mg. The results obtained, showed a varied response to the drug: decrease of acid secretion by 40% in half of the cases no influence or even increase of acid secretion in the rest of the cases. Correlation with the prevalent secretory type showed the inhibitory action of Verapamil in the beta-adrenergic-gastrin type thus pleading for an extracellular, probably membranous action of the drug.
在14例十二指肠溃疡患者中研究了钙通道抑制剂（维拉帕米）对刺激胃酸分泌的作用。每隔48小时进行两次组胺刺激（0.5毫克）胃酸分泌，第二次刺激前给予80毫克或120毫克剂量的维拉帕米。所获结果显示对该药有不同反应：一半病例胃酸分泌减少40%，其余病例无影响甚至胃酸分泌增加。与主要分泌类型的相关性表明维拉帕米对β-肾上腺素能-胃泌素型有抑制作用，因此证明该药有细胞外、可能是膜性作用。
