Kisfalvi I, Földvári P, Szücs K
Acta Med Acad Sci Hung. 1980;37(1):59-65.
Synthetic salmon calcitonin infused intravenously in a pharmacological dose of 2 MRCU/kg/hour resulted in an abrupt and profound inhibition of basal and pentagastrin and calcium induced gastric acid secretion in patients with duodenal ulcer. The inhibition in the sixth 15-minute period of the intravenous infusion of calcitonin amounted to 98.7% (basal acid secretion), 51.8% (pentagastrin-stimulated acid secretion) and 80.9% (calcium-induced acid secretion). There were no significant alterations in the serum calcium and gastrin levels during the intravenous infusion of calcitonin. The slight decrease in serum gastrin concentration in the first 30 minutes of calcitonin infusion cannot explain the strong inhibition of gastric acid secretion produced by calcitonin. It is assumed that calcitonin inhibits directly the parietal cells.
以2 MRCU/千克/小时的药理剂量静脉输注合成鲑鱼降钙素，可导致十二指肠溃疡患者的基础胃酸分泌以及由五肽胃泌素和钙诱导的胃酸分泌突然且显著受到抑制。在静脉输注降钙素的第6个15分钟期间，抑制率分别为98.7%（基础胃酸分泌）、51.8%（五肽胃泌素刺激的胃酸分泌）和80.9%（钙诱导的胃酸分泌）。在静脉输注降钙素期间，血清钙和胃泌素水平无显著变化。降钙素输注开始的前30分钟血清胃泌素浓度略有下降，这无法解释降钙素对胃酸分泌的强烈抑制作用。推测降钙素直接抑制壁细胞。
