中国社区睡眠呼吸障碍人群中夜间低氧血症与血脂异常的相关性：一项横断面研究。

The association of nocturnal hypoxemia with dyslipidemia in sleep-disordered breathing population of Chinese community: a cross-sectional study.

机构信息

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Sleep Center, Department of Respiratory and Critical Care MedicineGuangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)Yuexiu District, Southern Medical University, No.106 Zhongshan Road, Guangzhou City, Guangdong Province, China.

出版信息

Lipids Health Dis. 2023 Sep 26;22(1):159. doi: 10.1186/s12944-023-01919-8.

DOI:10.1186/s12944-023-01919-8

PMID:37752495

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10521560/

Abstract

BACKGROUND

Currently, there is limited and controversial clinical research on the correlation between sleep-disordered breathing (SDB) and dyslipidemia. This discrepancy in findings may be because studies that primarily focused on hospital-based populations may not be applicable to community-based populations. Therefore, the primary objective of this research endeavor is to scrutinize the correlation between nocturnal hypoxemia and blood lipid concentrations among adult individuals residing in the community who exhibit symptoms of SDB. Additionally, this study aimed to identify the nocturnal hypoxia parameters having the strongest correlation with this relationship.

METHODS

This cross-sectional study collected data from The Guangdong Sleep Health Study, which included 3829 participants. Type IV sleep monitoring was employed to measure hypoxemia parameters, and lipoproteins were evaluated using fasting blood samples. To understand the association between dyslipidemia and hypoxemia parameters, a multivariable logistic regression model was used. Subgroup analyses were conducted to stratify data according to age, sex, waist circumference, and chronic diseases.

RESULTS

The age of the individuals involved in the study spanned from 20 to 90 years. The average age of the participants was 56.15 ± 13.11 years. Of the total sample size, 55.7% were male. In the fully adjusted model, the meanSpO2 was negatively associated with hyperlipidemia (0.9303 [95% confidence interval 0.8719, 0.9925]). Upon conducting a nonlinearity test, the relationship between the meanSpO2 and hyperlipidemia was nonlinear. The inflection points were determined to be 95. When meanSpO2 ≥ 95%, a difference of 1 in the meanSpO2 corresponded to a 0.07 difference in the risk of hyperlipidemia.

CONCLUSIONS

This study revealed that higher meanSpO2 is significantly and negatively associated with hyperlipidemia in adult community residents with SDB, particularly when the meanSpO2 exceeds 95. This finding emphasizes the importance of close monitoring for dyslipidemia, which is considered an early indicator of atherosclerosis in patients with SDB who experience nocturnal hypoxia.

摘要

背景

目前，关于睡眠呼吸障碍（SDB）与血脂异常之间的相关性，临床研究有限且存在争议。这些研究结果的差异可能是因为主要关注医院人群的研究可能不适用于社区人群。因此，本研究的主要目的是研究社区中患有 SDB 症状的成年人中夜间低氧血症与血脂浓度之间的相关性。此外，本研究旨在确定与这种关系相关性最强的夜间低氧参数。

方法

这项横断面研究从广东睡眠健康研究中收集数据，共纳入 3829 名参与者。采用 IV 型睡眠监测来测量低氧血症参数，并用空腹血样评估脂蛋白。为了了解血脂异常与低氧血症参数之间的关系，使用多变量逻辑回归模型进行分析。进行了亚组分析，根据年龄、性别、腰围和慢性病对数据进行分层。

结果

参与者的年龄范围为 20 至 90 岁，平均年龄为 56.15±13.11 岁。在总样本中，55.7%为男性。在完全调整的模型中，平均 SpO2 与高脂血症呈负相关（0.9303[95%置信区间 0.8719，0.9925]）。进行非线性检验后，平均 SpO2 与高脂血症之间的关系是非线性的。拐点确定为 95。当平均 SpO2≥95%时，平均 SpO2 每增加 1，高脂血症的风险增加 0.07。