Johansson K E, Ask P, Boeryd B, Fransson S G, Tibbling L
Scand J Gastroenterol. 1986 Sep;21(7):837-47. doi: 10.3109/00365528609011128.
In a study comprising 100 patients referred to a surgical clinic with symptoms suggestive of gastro-oesophageal reflux disease the value of different diagnostic procedures was investigated. Positive acid perfusion and 24-h pH tests were the commonest findings. Forty-nine per cent showed a normal oesophageal mucosa or diffuse oesophagitis at endoscopy. The severity of heartburn and regurgitation did not differ between patients with normal oesophageal mucosa and oesophagitis of various severities. The severity of macroscopic oesophagitis was significantly correlated to the total reflux time, the presence of reflux or a hiatal hernia at radiology, an open cardia or reflux at endoscopy, pressure transmission or reflux and low lower oesophageal sphincter pressure at manometry. Gastric hypersecretion was found in 66% of the patients. Gastric acid secretion was not correlated to the severity of oesophagitis or to the findings at 24-h pH test. In patients with severe oesophagitis the sensitivity for radiologic, manometric, and endoscopic signs of incompetence of the gastro-oesophageal junction was 94%.
在一项针对100名因疑似胃食管反流病症状而转诊至外科诊所的患者的研究中，对不同诊断方法的价值进行了调查。阳性酸灌注试验和24小时pH测试是最常见的检查结果。49%的患者在内镜检查时食管黏膜正常或有弥漫性食管炎。食管黏膜正常的患者与不同严重程度食管炎患者的烧心和反流严重程度并无差异。内镜下食管炎的严重程度与总反流时间、放射检查时反流或食管裂孔疝的存在、内镜检查时贲门开放或反流、测压时压力传递或反流以及食管下括约肌压力降低显著相关。66%的患者存在胃酸分泌过多。胃酸分泌与食管炎的严重程度或24小时pH测试结果无关。在患有严重食管炎的患者中，胃食管交界处功能不全的放射学、测压和内镜检查征象的敏感度为94%。
