Børkje B, Odegaard S, Vetvik K, Skagen D W, Andersen K J, Laerum O D
Scand J Gastroenterol. 1986 Oct;21(8):928-34. doi: 10.3109/00365528608996397.
A series of mucosal enzymes were estimated by analysis of homogenized biopsy specimens from the lower duodenal flexure, obtained from 10 large-bowel carcinoma patients, 15 patients with morbid obesity, and 15 controls. In 11 subjects the distribution along the upper small intestine was determined. The activities of the brush border enzymes lactase (p less than 0.01), neutral-alpha-glucosidase (p less than 0.01), and alkaline phosphatase (p less than 0.05) were significantly lower in the large-bowel carcinoma patients than in the controls. In obese subjects significantly lower activities (p less than 0.05) were demonstrated for the basolateral membrane enzyme 5'-nucleotidase and the lysosomal enzymes N-acetyl-beta-D-glucosaminidase and acid beta-glucuronidase, when compared with those in controls. Compared with the enzyme levels of the duodenal bulb, significantly higher activities of a series of enzymes were demonstrated at both the lower duodenal flexure and the angle of Treitz.
通过对取自10例大肠癌患者、15例病态肥胖患者及15例对照者的十二指肠下曲匀浆活检标本进行分析，对一系列黏膜酶进行了评估。在11名受试者中测定了沿小肠上段的分布情况。大肠癌患者的刷状缘酶乳糖酶（p<0.01）、中性α-葡萄糖苷酶（p<0.01）和碱性磷酸酶（p<0.05）的活性显著低于对照组。与对照组相比，肥胖受试者的基底外侧膜酶5'-核苷酸酶以及溶酶体酶N-乙酰-β-D-氨基葡萄糖苷酶和酸性β-葡萄糖醛酸酶的活性显著降低（p<0.05）。与十二指肠球部的酶水平相比，十二指肠下曲和Treitz角处一系列酶的活性均显著更高。
