快照：癌症相关成纤维细胞。
SnapShot: Cancer-Associated Fibroblasts.
机构信息
Tumour Cell Biology Laboratory, Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Tumour Cell Biology Laboratory, Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK; Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
出版信息
Cell. 2020 Apr 16;181(2):486-486.e1. doi: 10.1016/j.cell.2020.03.013.
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment and have both tumor-promoting and tumor-suppressive functions. This SnapShot summarizes the origins of CAFs, their diverse functions, and how this relates to heterogeneity within the population. The suitability of targeting CAFs therapeutically is also discussed.
癌症相关成纤维细胞（CAFs）是肿瘤微环境的一个组成部分，具有促进肿瘤和抑制肿瘤的双重功能。本 SnapShot 总结了 CAFs 的起源、它们的多种功能，以及这与群体内异质性的关系。还讨论了靶向 CAFs 治疗的适用性。
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