两种催化从L.形成芦丁的高效糖基转移酶的功能表征
Functional characterization of two efficient glycosyltransferases catalysing the formation of rutin from L.
作者信息
Zou Jianlin, Li Hongye, Wang Zilong, Ye Min
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
出版信息
Org Biomol Chem. 2023 Oct 11;21(39):7913-7916. doi: 10.1039/d3ob01281f.
Two efficient and selective glycosyltransferases were identified from L. Sj3GT could regio-selectively catalyse 3--glucosylation of quercetin to produce isoquercitrin, and Sj6''RhaT could further catalyse its 6''--rhamnosylation to generate rutin. It is particularly noteworthy that Sj6''RhaT shows high sugar donor selectivity towards UDP-rhamnose.
从[具体来源未给出，推测是某种植物或微生物等]中鉴定出两种高效且具有选择性的糖基转移酶。Sj3GT可以区域选择性地催化槲皮素的3-O-葡萄糖基化反应生成异槲皮苷，并且Sj6''RhaT可以进一步催化其6''-O-鼠李糖基化反应生成芦丁。特别值得注意的是，Sj6''RhaT对UDP-鼠李糖表现出高糖供体选择性。
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