Wang Jie-Lin, Hua Sheng-Ni, Bao Hai-Juan, Yuan Jing, Zhao Yang, Chen Shuo
Department of Obstetrics and Gynecology Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China.
Department of Gynecologic Oncology Research Office Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China.
MedComm (2020). 2023 Sep 24;4(5):e374. doi: 10.1002/mco2.374. eCollection 2023 Oct.
Nonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell death. Cell death is significantly linked to tumor development, medication resistance, cancer recurrence, and metastatic dissemination. Therefore, a comprehensive understanding of cell death is essential for the treatment of cancer. Pyroptosis is a kind of PCD distinct from autophagy and apoptosis in terms of the structure and function of cells. The defining features of pyroptosis include the release of an inflammatory cascade reaction and the expulsion of lysosomes, inflammatory mediators, and other cellular substances from within the cell. Additionally, it displays variations in osmotic pressure both within and outside the cell. Pyroptosis, as evidenced by a growing body of research, is critical for controlling the development of inflammatory diseases and cancer. In this paper, we reviewed the current level of knowledge on the mechanism of pyroptosis and inflammasomes and their connection to cancer and inflammatory diseases. This article presents a theoretical framework for investigating the potential of therapeutic targets in cancer and inflammatory diseases, overcoming medication resistance, establishing nanomedicines associated with pyroptosis, and developing risk prediction models in refractory cancer. Given the link between pyroptosis and the emergence of cancer and inflammatory diseases, pyroptosis-targeted treatments may be a cutting-edge treatment strategy.
非程序性细胞死亡（NPCD）和程序性细胞死亡（PCD）是两种细胞死亡类型。细胞死亡与肿瘤发展、耐药性、癌症复发和转移扩散密切相关。因此，全面了解细胞死亡对于癌症治疗至关重要。细胞焦亡是一种程序性细胞死亡，在细胞结构和功能方面有别于自噬和凋亡。细胞焦亡的决定性特征包括炎症级联反应的释放以及溶酶体、炎症介质和其他细胞内物质从细胞内排出。此外，它在细胞内外均表现出渗透压变化。越来越多的研究表明，细胞焦亡对于控制炎症性疾病和癌症的发展至关重要。在本文中，我们综述了目前关于细胞焦亡和炎性小体机制及其与癌症和炎症性疾病联系的知识水平。本文提出了一个理论框架，用于研究癌症和炎症性疾病中治疗靶点的潜力、克服耐药性、建立与细胞焦亡相关的纳米药物以及开发难治性癌症的风险预测模型。鉴于细胞焦亡与癌症和炎症性疾病发生之间的联系，靶向细胞焦亡的治疗可能是一种前沿的治疗策略。
